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RISS 인기검색어
- 검색키워드
- 저자 : Nagamma, T. (검색결과 2 건)
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Status of Oxidative Stress and Antioxidant Levels in Smokers with Breast Cancer from Western Nepal
Nagamma, T.,Baxi, Jalaj,Singh, P.P. Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: Research indicates that oxidative stress induced by smoking plays a role in breast cancer. In view of these reports, we aimed to study th relationship between smoking and oxidative stress in breast cancer patients from the western region of Nepal. Materials and Methods: The study included a control group of 42 females (non-smoking healthy women) and a test group sudivided into Group I consisting of 46 female breast cancer patients who were smokers and Group II consisting of 42 non-smoking breast cancer patients. Detailed history of the patients was collected with the help of pre-test proforma. Plasma levels of malondialdehyde (MDA), total antioxidant activity (TAA) which represents total dietary antioxidants, vitamin C and ${\alpha}$- tocopherol were estimated by standard methods. Statistical analysis was done using SPSS version 16. Results: The plasma MDA, TAA, vitamin C and ${\alpha}$- tocopherol were $1{\pm}1.4nmol/ml$, $918{\pm}207{\mu}mol/L$, $1{\pm}0.24mg/dL$ and $0.94{\pm}0.31mg/dL$ in controls, $5{\pm}1.2nmol/ml$, $458{\pm}166{\mu}mol/L$, $0.64{\pm}0.32mg/dL$ and $0.5{\pm}0.3mg/dL$ in Group-I and $2.56{\pm}1.2nmol/ml$, $663{\pm}178{\mu}mol/L$, $0.78{\pm}0.2mg/dL$ and $0.77{\pm}0.2mg/dL$ in Group- II, respectively. Vitamin C, ${\alpha}$- tocopherol and TAA (p=0.001) were significantly reduced whereas MDA (p=0.001) was significantly raised in Group-I when compared to controls and Group-II. Conclusions: We observed a significant rise in oxidative stress and low levels of antioxidants in breast cancer patients with smoking habit. It is well known that free radicals facilitate the progression of breast cancer, possibly increasing the risk of progression to the next stage.
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Nagamma, T.,Bhutia, Rinchen Doma,Pokharel, Daya Ram,Yadav, Saraswati,Baxi, J. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Aim: The present study assess the effect of consumption of alcohol on oxidative stress and antioxidant status in patients suffering from different types of cancer. Methods: This hospital based case control study conducted in the Western part of Nepal covered a total of 93 cancer patients with or without alcohol intake and smoking habits, along with 94 age, sex and habit-matched individuals serving as controls. Plasma thiobarbituric acid reacting substances (TBARS), total antioxidant activity (TAA), vitamin C, ${\alpha}$-tocopherol and erythrocyte reduced glutathione (GSH) were estimated and compared. Results: The TBARS level was found to be significantly higher ($p{\leq}0.001$) in all types of cancer patients when compared to controls, being aggravated in alcoholics with a smoking habit. No statistical significance ($p{\geq}0.05$) was observed in the level of vitamin C and ${\alpha}$-tocopherol. GSH and TAA level were significantly decreased ($p{\leq}0.001$) in all the groups except those who consumed both branded as well as homemade alcohol and non-alcoholics without smoking habit. Conclusion: Alcohol, irrespective of its commercial brand, increases oxidative stress in all types of cancer patients. This is even higher when alcohol intake is combined with a smoking habit. Decreased TAA and GSH are major risk factors for cancer development.
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