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Tania Parvin,Mim Binti Akhlas,Fatema Khatun,Anzuman Akter,Md. Al Amin,Muhammad Torequl Islam,Razina Rouf 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
This study aimed at phytochemical analysis and evaluation of toxic and protective efects of the crude aqueous extract of Typhonium trilobatum. Toxicity analysis was done in Allium cepa, while anti-infammatory, and membrane stabilizing and clotlysis capacity were tested by using egg albumin and human erythrocytes, respectively. The results suggest that T. trilobatum aqueous extract contains alkaloids, glycosides, tannins, saponins, favonoids and reducing sugars. The crude extract exhibited toxicity in A. cepa in a time and concentration dependent manner. The highest root growth inhibition was observed at exposure time 72 h in 20% (v/v) concentration extract of the herb. The extract at low concentration (2.5 and 5%) reduced the root growth inhibition capacity at 48 h in comparison to 24 and 72 h, possibly by adaptation of DNA damage profle in the eukaryotic test system (A. cepa), which was further confrmed in anti-infammatory and membrane stabilizing, and anti-atherothrombosis test. In the latter cases, the extract at 0.02–0.08% (v/v) signifcantly (p<0.05, p<0.01, p<0.001) inhibited protein denaturation, membrane lysis, while enhanced clotlysis capacity in a concentration-dependent manner. In conclusion, the extract exerted toxic efects at high concentrations and protective efects at low concentrations. T. trilobatum may be one of the potential sources of phytotherapeutic agents, especially for the treatment of infammatory and cardiovascular diseases and disorders.