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Zhiguo Zhao,Mengna Li,Chen Wang,Lanxing Jiang,Maoyao Wang 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.3
Since the mode transition performance of power-split DHT (Dedicated Hybrid Transmission) are directly influenced by torque dynamic characteristic of the brake, the brake pressure should be controlled accurately. In this paper, a dynamic model of brake and its pressure regulating system are established by considering system nonlinear characteristics and input disturbances, and a sliding mode variable structure controller is developed to track the brake pressure. First, the operation principle of DHT's pressure regulating system is introduced. Second, the dynamic models of solenoid proportional pressure valve, electromagnetic direction switching valve and brake are established with AMESim parametric plant model. Furthermore, a sliding mode variable structure controller for tracking pressure is designed based on MATLAB/Simulink. Finally, the AMESim parametric plant model is validated by measurements, and the proposed controller are verified by AMESim and Simulink co-simulation. The results show that the system dynamics can be well characterized by the AMESim parametric plant model. The target pressure can be tracked rapidly and accurately by using sliding mode variable structure controller and the controller has better robustness.
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Zheng Jun,Huang Ju,Zhang Liang,Wang Mengna,Xu Lihong,Dou Xiaoyun,Leng Xiaojing,Fang Mingxiao,Sun Yang,Wang Zhigang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Although programmed cell death protein 1 (PD-1)/ programmed cell death-ligand protein 1 (PD-L1) checkpoint blockade immunotherapy demonstrates great promise in cancer treatment, poor infiltration of T cells resulted from tumor immunosuppressive microenvironment (TIME) and insufficient accumulation of anti-PD-L1 (αPD-L1) in tumor sites diminish the immune response. Herein, we reported a drug-loaded microbubble delivery system to overcome these obstacles and enhance PD-L1 blockade immunotherapy.Docetaxel (DTX) and imiquimod (R837)-loaded microbubbles (RD@MBs) were synthesized via a typical rotary evaporation method combined with mechanical oscillation. The targeted release of drugs was achieved by using the directional "bursting" capability of ultrasound-targeted microbubble destruction (UTMD) technology. The antitumor immune response by RD@MBs combining αPD-L1 were evaluated on 4T1 and CT26 tumor models.The dying tumor cells induced by DTX release tumor-associated antigens (TAAs), together with R837, promoted the activation, proliferation and recruitment of T cells. Besides, UTMD technology and DTX enhanced the accumulation of αPD-L1 in tumor sites. Moreover, RD@MBs remolded TIME, including the polarization of M2-phenotype tumor-associated macrophages (TAMs) to M1-phenotype, and reduction of myeloid-derived suppressor cells (MDSCs). The RD@MBs + αPD-L1 synergistic therapy not only effectively inhibited the growth of primary tumors, but also significantly inhibited the mimic distant tumors as well as lung metastases.PD-L1 blockade immunotherapy was enhanced by RD@MBs delivery system.
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Zhou, Xiufeng,Lu, Juan,Jiang, Jingjing,Li, Xiaobin,Lu, Mengna,Yuan, Guotao,Wang, Zuoshan,Zheng, Min,Seo, Hyo Jin Springer 2014 NANOSCALE RESEARCH LETTERS Vol.9 No.1
<P>N-doped mesoporous TiO<SUB>2</SUB> nanorods were fabricated by a modified and facile sol–gel approach without any templates. Ammonium nitrate was used as a raw source of N dopants, which could produce a lot of gasses such as N<SUB>2</SUB>, NO<SUB>2</SUB>, and H<SUB>2</SUB>O in the process of heating samples. These gasses were proved to be vitally important to form the special mesoporous structure. The samples were characterized by the powder X-ray diffraction, X-ray photoelectron spectrometer, nitrogen adsorption isotherms, scanning electron microscopy, transmission electron microscopy, and UV-visible absorption spectra. The average length and the cross section diameter of the as-prepared samples were <I>ca</I>. 1.5 μm and ca. 80 nm, respectively. The photocatalytic activity was evaluated by photodegradation of methylene blue (MB) in aqueous solution. The N-doped mesoporous TiO<SUB>2</SUB> nanorods showed an excellent photocatalytic activity, which may be attributed to the enlarged surface area (106.4 m<SUP>2</SUP> g<SUP>-1</SUP>) and the narrowed band gap (2.05 eV). Besides, the rod-like photocatalyst was found to be easy to recycle.</P>
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Yamei Xu,Qiyuan Hu,Zongyun Wei,Yi Ou,Youde Cao,Hang Zhou,Mengna Wang,Kexiao Yu,Bing Liang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient’s recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer dressings and hydrogels to solve the therapeutic bottleneck of DU treatment. Hydrogels are a class of gels with a three-dimensional network structure that have good moisturizing properties and permeability and promote autolytic debridement and material exchange. Moreover, hydrogels mimic the natural environment of the extracellular matrix, providing suitable surroundings for cell proliferation. Thus, hydrogels with different mechanical strengths and biological properties have been extensively explored as DU dressing platforms. In this review, we define different types of hydrogels and elaborate the mechanisms by which they repair DUs. Moreover, we summarize the pathological process of DUs and review various additives used for their treatment. Finally, we examine the limitations and obstacles that exist in the development of the clinically relevant applications of these appealing technologies.
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