RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재

        Role of platelet CD40 ligand for endothelial cell-monocyte interaction in the presence of flow

        Andreas H. Wagner,Manuel Schwarz,Gerd König,Markus Hecker 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.4

        CD40 ligand (CD154)-induced ultra-large von Willebrand factor (vWF) multimer-mediated endothelial cellplatelet-monocyte interaction may play an important role in adaptive and maladaptive vascular remodelingprocesses. Here we analyzed the impact of and conditions favouring the deposition of these multimers onthe endothelial cell (EC) surface by way of CD40-CD154 co-stimulation in settings mimicking differentforms of blood flow. Upon exposure to low oscillatory shear stress and sCD154, a release of vWF multimerscomparable to histamine stimulation was monitored on the EC surface in a string-like fashion. Moreover,ex vivo perfused carotid arteries of wild type mice at low laminar shear stress rates showed a luminalrelease of vWF as ultra-large vWF multimers (ULVWF) upon stimulation with sCD154 which was absentin blood vessels of CD40 knockout mice. The observed CD40- and flow-dependent vWF release from intactendothelial cells and subsequent vWF multimer formation may facilitate adhesion and subsequent activationof circulating platelets at atherosclerotic predilection sites, which are characterized by disturbed flow patterns. This in turn may amplify endothelial cell-monocyte interaction, thus possibly initiating or promotingearly atherosclerotic lesion formation.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼