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- 저자 : Kima, Jong-ho (검색결과 100 건)
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Kim, A.,Kim, M.-J.,Yang, Y.,Kim, J. W.,Yeom, Y. I.,Lim, J.-S. Oxford University Press 2009 Carcinogenesis Vol.30 No.6
<P>Downregulation of the N-myc downstream-regulated gene 2 (NDRG2) gene is involved in the progression of aggressive forms of cancer, along with the poor prognosis of cancer patients. In the current study, we examined the effect of NDRG2 expression on the metastatic potential of HT1080 human fibrosarcoma and B16F10 murine melanoma cells in both in vitro and in vivo systems. In gelatin zymography, NDRG2 expression remarkably suppressed the matrix metalloproteinase (MMP)-9 activity and slightly inhibited MMP-2 activity of both cell lines. Tumor migration and invasion in vitro were significantly reduced by NDRG2 expression, and NDRG2 inhibited tumor cell proliferation in an anchorage-independent semisolid agar assay. Specifically, we found that NDRG2 affects invasion through suppression of nuclear factor kappa B (NF-kappa B) activity. In animal experiments, subcutaneously injected B16F10-NDRG2 cells showed delayed tumor growth compared with B16F10-mock cells. Furthermore, severe metastasis from primary tumor mass into the draining lymph nodes was observed after injection of B16F10-mock cells, but not with B16F10-NDRG2 cells. Pulmonary metastasis after intravenous injection of B16F10 cells was also reduced by NDRG2 expression. Intra- and peritumoral angiogenesis that is critical for the tumor growth and metastasis was clearly found in tumors after injection with B16F10-mock cells, whereas it was impaired in tumors after injection with B16F10-NDRG2 cells. Collectively, our data show that NDRG2 expression significantly suppresses tumor invasion by inhibiting MMP activities, which are regulated through the NF-kappa B signaling. Moreover, results from animal experiments provide evidence for the regulatory role of the NDRG2 gene in metastatic tumors.</P>
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Kim, A.,Gweon, G. Pergamon 2016 Computers in Human Behavior Vol.62 No.-
Picture sharing activity on social networking sites helps create and maintain social relationships. However, some of these pictures can be undesirable digital traces especially when the person sharing the information (owner) and the person receiving the information (viewer) do not ask the sharing preference of the person who is in the picture (subject). In our exploratory lab study, we asked twenty-nine participants about their picture sharing preference (PSP) towards an owner's act of sharing a photograph containing both the participant (subject) and the owner with a viewer. Our multi-level regression on 5520 data points show that in terms of closeness, a subject feels more comfortable sharing a picture i) as the ''closeness between the subject and the owner (SO closeness)'' increases and ii) as the ''closeness between the subject and the viewer (SV closeness)'' increases. In terms of ownership, a subject feels more comfortable with sharing a picture i) when the picture shows a greater number of people as opposed to a smaller number of people, and ii) when the picture is captured at an event held for the viewer or the owner rather than for the subject. In addition, we observed three types of interaction effects on PSP between the following variables: i) SO closeness and SV closeness, ii) SO closeness and num_people, and iii) both types of closeness and event_posessor.
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Synthesis and antibacterial evaluation of hamacanthin B analogues
Kim, A.,Kim, M.J.,Noh, T.H.,Hong, J.,Liu, Y.,Wei, X.,Jung, J.H. Pergamon Press 2016 Bioorganic & medicinal chemistry letters Vol.26 No.20
Hamacanthins are a class of antibacterial bisindole alkaloids isolated from marine sponges. Based on structure-activity relationships and in silico MRSA PK binding analysis of these bisindole alkaloids, the authors designed new hamacanthin B derivatives and evaluated their antibacterial activities against drug-resistant pathogens. Racemates of the synthetic products were resolved into their enantiomers by chiral separation using a cellulose column, and antibacterial activities were compared. Unsaturation of the central heterocyclic ring structure and bromine substitution at the indole moiety were found to enhance the antibacterial activities of hamacanthin B analogues.
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Kim, A.,Lee, J.,Kim, B.G.,Lee, D.J.,Jung, H. Elsevier [etc.] 2017 Journal of luminescence Vol.190 No.-
The fluorescent solid material, which emits highly efficient deep-blue light, was successfully fabricated by stabilized 9,10-diphenylanthracene (DPA) molecules in mesostructured silica material (MSM) (referred to as DPA-MSM). The DPA molecules are favorably introduced into the hydrophobic domain of a self-assembled amphiphilic triblock copolymer (poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Pluronic P123) template through a one-pot synthetic route based on the van der Waals interaction. Powder X-ray diffraction patterns show that the unit-cell parameter of DPA-MSM was 1.2nm larger than that of pure MSM, along with the well-ordered hexagonal structure. The photophysical properties of DPA-MSM have been studied and compared with those of DPA in solution (0.15mM) and powdered states, respectively. Both absorption and emission maxima of the immobilized DPA show a remarkable hypsochromic shift as compared with those of pure DPA powder. In addition, we have observed distinct spectral features in the DPA-MSM, which resemble those of DPA dissolved in cyclohexane, indicating that the immobilized DPA is molecularly separated by the interactions with the poly(propylene glycol) part in P123. The fluorescence decay behavior showed that DPA-MSM has a longer lifetime because the intramolecular motions of DPA are strongly restricted by the confined environment within the pore channel of rigid MSM. These results also show that the immobilized DPA has a higher fluorescence quantum yield than did DPA in dissolved or powdered states. The fabricated blue LED chip with DPA-MSM exhibited outstanding deep-blue color with CIE coordinates of (0.15, 0.03). It was found that the incorporation of DPA in MSM provides an efficient blue emitter in the solid-state.
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Kim, A.,Im, M.,Ma, J. Y. Spandidos Publications 2016 Oncology reports Vol.35 No.3
<P>Cachexia accompanied by muscle wasting is a key determinant of poor prognosis in cancer patients and cancer-related death. Previous studies have demonstrated that inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), IL-1 and interferon-gamma (IFN-gamma) secreted from host cells and tumor cells participate in skeletal muscle wasting followed by severe loss of body weight. Therefore, blockade of the inflammatory response is thought to be a logical target for pharmacological and nutritional interventions to preserve skeletal muscle mass under cachectic conditions. Sosiho-tang (SO; Xiaocharihu-tang in Chinese and Sho-saiko-to in Japanese) is an Oriental herbal medicine that has been used to treat chronic hepatic diseases and to control fever. In recent studies, SO inhibited the production of inflammatory cytokines in lipopolysaccharide (LPS)-stimulated macrophages, prevented thrombus formation and suppressed cancer progression. However, the anti-cachectic activity of SO in tumor-bearing mice has not yet been examined. In the present study, we characterized the effect of SO administration on cancer-induced cachexia in CT-26-bearing mice, and elucidated the anti-cachectic mechanisms. Daily oral administration of SO at doses of 50 and 100 mg/kg to CT-26-bearing mice significantly retarded tumor growth and prevented the loss of final body weight, carcass weight, heart weight, gastrocnemius muscle, and epididymal fat, compared with saline-treated control mice. In addition, serum IL-6 levels elevated by cancer were decreased by SO administration. In the J774A.1 macrophage cell line, SO efficiently suppressed LPS-mediated increases in inducible nitric oxide synthase (iNOS) expression, nitric oxide (NO), and procachectic inflammatory cytokine production through inhibition of nuclear factor-kappa B (NF-kappa B) and p38 activation. In addition, SO attenuated muscle atrophy caused by cancer cells by affecting myoblast proliferation and differentiation, and C2C12 myotube wasting. Taken together, these results suggest that SO is a safe and useful anti-cachectic therapy for cancer patients with severe weight loss.</P>
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Kim, A.,Lee, H.,Kwon, H. C.,Jung, H.,Park, N. G.,Jeong, S.,Moon, J. Royal Society of Chemistry 2016 Nanoscale Vol.8 No.12
<P>We report all-solution-processed transparent conductive electrodes based on Ag nanowire (AgNW)-embedded metal oxide composite films for application in organometal halide perovskite solar cells. To address the thermal instability of Ag nanowires, we used combustive sol-gel derived thin films to construct ZnO/ITO/AgNW/ITO composite structures. The resulting composite configuration effectively prevented the AgNWs from undergoing undesirable side-reactions with halogen ions present in the perovskite precursor solutions that significantly deteriorate the optoelectrical properties of Ag nanowires in transparent conductive films. AgNW-based composite electrodes had a transmittance of similar to 80% at 550 nm and sheet resistance of 18 Omega sq(-1). Perovskite solar cells fabricated using a fully solution-processed transparent conductive electrode, Au/spiro-OMeTAD/CH3NH3PbI3 + m-Al2O3/ZnO/ITO/AgNW/ITO, exhibited a power conversion efficiency of 8.44% (comparable to that of the FTO/glass-based counterpart at 10.81%) and were stable for 30 days in ambient air. Our results demonstrate the feasibility of using AgNWs as a transparent bottom electrode in perovskite solar cells produced by a fully printable process.</P>
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Development and Applications of 3-Dimensional Integration Nanotechnologies
Kim, A.,Choi, E.,Son, H.,Pyo, S.G. American Scientific Publishers 2014 Journal of nanoscience and nanotechnology Vol.14 No.2
Unlike conventional two-dimensional (2D) planar structures, signal or power is supplied through through-silicon via (TSV) in three-dimensional (3D) integration technology to replace wires for binding the chip/wafer. TSVs have becomes an essential technology, as they satisfy Moore's law. This 3D integration technology enables system and sensor functions at a nanoscale via the implementation of a highly integrated nano-semiconductor as well as the fabrication of a single chip with multiple functions. Thus, this technology is considered to be a new area of development for the systemization of the nano-bio area. In this review paper, the basic technology required for such 3D integration is described and methods to measure the bonding strength in order to measure the void occurring during bonding are introduced. Currently, CMOS image sensors and memory chips associated with nanotechnology are being realized on the basis of 3D integration technology. In this paper, we intend to describe the applications of high-performance nano-biosensor technology currently under development and the direction of development of a high performance lab-on-a-chip (LOC).
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