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State and Parameter Estimation for Tubular Microreactors Using Particle Filter
Jun-ichi Kano,Osamu Tonomura,Manabu Kano,Shinji Hasebe 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Micro Chemical Processes (MCPs) are constructed of micrometer scale channels. The characteristics of MCPs are rapid mixing due to short diffusion distances and accurate temperature control due to large surface-volume ratio. Therefore, MCPs make it possible to realize the production of specialty chemicals, which cannot be handled in conventional processes. To realize stable long-term operation of MCPs, it is necessary to detect the catalyst deterioration and the blockage which are the critical problems in the operation of MCPs. For example, the catalyst deterioration and the blockage are detected through the concentration meters and the flow meters installed in microchannels respectively. However, the installation of such sensors sometimes disturbs the flow. In addition, the existing miniaturized sensors are too expensive. Therefore, it is necessary to develop a monitoring system of MCPs using the state and parameter estimation. In this work, a monitoring system based on physical models and wall temperature measurements for Tubular Microreactor (TMR) is developed. It is described that Particle Filter (PF) can detect the catalyst deterioration of TMR more rapidly and accurately than Extended Kalman Filter (EKF).
Kano, Hideyuki,Kondziolka, Douglas,Flickinger, John C,Yang, Huai-che,Park, Kyung-Jae,Flannery, Thomas J,Liu, Xiaomin,Niranjan, Ajay,Lunsford, L Dade American Heart Association] 2012 Stroke Vol.43 No.10
<P>The purpose of this study was to define the risk of rebleeding after stereotactic radiosurgery (SRS) for hemorrhagic arteriovenous malformations with or without associated intracranial aneurysms.</P>
Stereotactic radiosurgery for arteriovenous malformations after embolization: a case-control study
Kano, Hideyuki,Kondziolka, Douglas,Flickinger, John C.,Park, Kyung-Jae,Iyer, Aditya,Yang, Huai-che,Liu, Xiaomin,Monaco, Edward A.,Niranjan, Ajay,Lunsford, L. Dade Journal of Neurosurgery Publishing Group 2012 Journal of Neurosurgery Vol.117 No.2
<B>Object</B><P>In this paper the authors' goal was to define the long-term benefits and risks of stereotactic radiosurgery (SRS) for patients with arteriovenous malformations (AVMs) who underwent prior embolization.</P><B>Methods</B><P>Between 1987 and 2006, the authors performed Gamma Knife surgery in 996 patients with brain AVMs; 120 patients underwent embolization followed by SRS. In this series, 64 patients (53%) had at least one prior hemorrhage. The median number of embolizations varied from 1 to 5. The median target volume was 6.6 cm<SUP>3</SUP> (range 0.2-26.3 cm<SUP>3</SUP>). The median margin dose was 18 Gy (range 13.5-25 Gy).</P><B>Results</B><P>After embolization, 25 patients (21%) developed symptomatic neurological deficits. The overall rates of total obliteration documented by either angiography or MRI were 35%, 53%, 55%, and 59% at 3, 4, 5, and 10 years, respectively. Factors associated with a higher rate of AVM obliteration were smaller target volume, smaller maximum diameter, higher margin dose, timing of embolization during the most recent 10-year period (1997-2006), and lower Pollock-Flickinger score. Nine patients (8%) had a hemorrhage during the latency period, and 7 patients died of hemorrhage. The actuarial rates of AVM hemorrhage after SRS were 0.8%, 3.5%, 5.4%, 7.7%, and 7.7% at 1, 2, 3, 5, and 10 years, respectively. The overall annual hemorrhage rate was 2.7%. Factors associated with a higher risk of hemorrhage after SRS were a larger target volume and a larger number of prior hemorrhages. Permanent neurological deficits due to adverse radiation effects (AREs) developed in 3 patients (2.5%) after SRS, and 1 patient had delayed cyst formation 210 months after SRS. No patient died of AREs. A larger 12-Gy volume was associated with higher risk of symptomatic AREs. Using a case-control matched approach, the authors found that patients who underwent embolization prior to SRS had a lower rate of total obliteration (p = 0.028) than patients who had not undergone embolization.</P><B>Conclusions</B><P>In this 20-year experience, the authors found that prior embolization reduced the rate of total obliteration after SRS, and that the risks of hemorrhage during the latency period were not affected by prior embolization. For patients who underwent embolization to volumes smaller than 8 cm<SUP>3</SUP>, success was significantly improved. A margin dose of 18 Gy or more also improved success. In the future, the role of embolization after SRS should be explored.</P>
Development of Simulator of Allophone of Motors for Automobiles
Ryo Kano,Hiroyasu Ohtake,Yoshifumi Morita,Makoto Iwasaki,Hiroyuki Ukai,Yasuhiko Mukai,Hideki Kabune,Norihisa Ito 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
Recently reduction of allophone of motors for automobiles has received a great deal of attention. For this background, the final goal of our research is to develop a simulator for transfer characteristics of allophone of motors in automobiles. In this paper at the preparation phase for the development of a simulator, we investigated the applicability of the transfer function synthesis method (TFSM) experimentally. Additionally, we examined some problems to be solved for practical use of the TFSM by using the finite element method (FEM). As a result, it was found that the derivation of the transfer functions H22 and H33 at the connecting point was difficult and that the modeling accuracy of H22 and H33 had a large influence on the modeling accuracy of the total transfer function H41_sim. Moreover, the method to improve the modeling accuracy was proposed on the basis of the results by FEM analysis. It was confirmed that we could apply the TFSM to the simple test body with the contact area by using the proposed method and the adjustment for damping coefficient of the transfer function obtained by the curve fitting technique (CFT).
( Michiko Kano ),( Patrick Dupont ),( Qasim Aziz ),( Shin Fukudo ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.4
This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses in regions related to sensory processing of the homeostatic condition of the gut (homeostatic afferent) and responses to salience stimuli (salience network), as well as increased and decreased brain activity in the emotional response areas and reduced activation in areas associated with the top-down modulation of visceral afferent signals. Altered central regulation of the endocrine and autonomic nervous responses, the key mediators of the brain-gut axis, has been demonstrated. Studies using resting-state functional magnetic resonance imaging reported abnormal local and global connectivity in the areas related to pain processing and the default mode network (a physiological baseline of brain activity at rest associated with self-awareness and memory) in FGIDs. Structural imaging with brain morphometry and diffusion imaging demonstrated altered gray- and white-matter structures in areas that also showed changes in functional imaging studies, although this requires replication. Molecular imaging by magnetic resonance spectroscopy and positron emission tomography in FGIDs remains relatively sparse. Progress using analytical methods such as machine learning algorithms may shift neuroimaging studies from brain mapping to predicting clinical outcomes. Because several factors contribute to the pathophysiology of FGIDs and because its population is quite heterogeneous, a new model is needed in future studies to assess the importance of the factors and brain functions that are responsible for an optimal homeostatic state. (J Neurogastroenterol Motil 2018;24:512-527)