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Cho, Hong Y.,Srinivasan, Abiraman,Hong, Joanna,Hsu, Eric,Liu, Shiguang,Shrivats, Arun,Kwak, Dan,Bohaty, Andrew K.,Paik, Hyun-jong,Hollinger, Jeffrey O.,Matyjaszewski, Krzysztof American Chemical Society 2011 Biomacromolecules Vol.12 No.10
<P>Star polymers with poly(ethylene glycol) (PEG) arms and a degradable cationic core were synthesized by the atom transfer radical copolymerization (ATRP) of poly(ethylene glycol) methyl ether methacrylate macromonomer (PEGMA), 2-(dimethylamino)ethyl methacrylate (DMAEMA), and a disulfide dimethacrylate (cross-linker, SS) via an “<I>arm-first</I>” approach. The star polymers had a diameter ∼15 nm and were degraded under redox conditions by glutathione treatment into individual polymeric chains due to cleavage of the disulfide cross-linker, as confirmed by dynamic light scattering. The star polymers were cultured with mouse calvarial preosteoblast-like cells, embryonic day 1, subclone 4 (MC3T3-E1.4) to determine biocompatibility. Data suggest star polymers were biocompatible, with ≥80% cell viability after 48 h of incubation even at high concentration (800 μg/mL). Zeta potential values varied with N/P ratio confirming complexation with siRNA. Successful cellular uptake of the star polymers in MC3T3-E1.4 cells was observed by confocal microscopy and flow cytometry after 24 h of incubation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-10/bm2006455/production/images/medium/bm-2011-006455_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm2006455'>ACS Electronic Supporting Info</A></P>