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Edith E. Lopéz-Martínez,Jesús A. Claudio-Rizo,Martín Caldera-Villalobos,Juan J. Becerra-Rodríguez,Denis A. Cabrera-Munguía,Lucía F. Cano-Salazar,Rebeca Betancourt-Galindo 한국고분자학회 2022 Macromolecular Research Vol.30 No.6
Determining the controlled release capacity of drugs with therapeutic interest as well as the biocompatibility of hydrogels based on natural and synthetic polymers is of the utmost importance to evaluate their potential performance in regenerative medicine strategies. Novel hydrogels were synthesized by semi-interpenetration of guar gum (GG) in a matrix of crosslinked collagen with hydrophilic polyurethane. GG concentrations of 10, 20, 30 and 40 wt% on the semi-IPN matrices were tested. These hydrogels have excellent in vitro biocompatibility, not demonstrating cytotoxic character for cells important in the healing process such as monocytes and fibroblasts, stimulating their proliferation, as well as evidencing hemocompatibility and antibacterial capacity. Also these matrices can encapsulate and release methylene blue in a controlled manner. The results of the evaluation of human monocyte signaling indicate that the semi-IPN matrix containing 30 wt% of GG allows higher segregation of beta-1 transforming growth factor (β1-TGF), a determinant cytokine in the construction of new tissue, showing that these hydrogels have potential application in biomedicine as dressings for chronic wound healing.
Edith E. Lopéz-Martínez,Jesús A. Claudio-Rizo,Martín Caldera-Villalobos,Juan J. Becerra-Rodríguez,Denis A. Cabrera-Munguía,Lucía F. Cano-Salazar,Rebeca Betancourt-Galindo 한국고분자학회 2022 Macromolecular Research Vol.30 No.6
Novel synthetic strategies to produce biopolymer based hydrogels for biomedical applications are required currently. Collagen hydrogels for wound healing can improve their structural and physicochemical properties by incorporating polysaccharides within the fibrillar matrix. Novel hydrogels were synthesized by semi-interpenetration of guar gum (GG) in a matrix of crosslinked collagen with hydrophilic polyurethane. GG concentrations of 10, 20, 30, and 40 wt% on the semi- IPN matrices were tested. The addition of the polysaccharide accelerates the gelling time of the hydrogels; 30 wt% of GG allows a 68 ± 5% of physicochemical crosslinking, exhibiting a maximum swelling of 3496 ± 89% and both improved mechanical and thermal resistance. The short-range interactions established in these matrices, mainly of the hydrogen bond type, make it possible to delay their hydrolytic and proteolytic degradation. The structure and properties of these hydrogels could have potential application in biomedicine as dressings for chronic wound healing, tailoring the controlled release of drugs with therapeutic interest, cell viability and proliferation, cell signaling, hemocompatibility and antibacterial character.