http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeong, Lak Shin,Yoo, Su Jeong,Lee, Kang Man,Koo, Mi Jeong,Choi, Won Jun,Kim, Hea Ok,Moon, Hyung Ryong,Lee, Min Young,Park, Jae Gyu,Lee, Sang Kook,Chun, Moon Woo 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Fluoroneplanocin A (12) was designed as a novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase (SAH) and efficiently synthesized via an electrophilic vinyl fluorination reaction (n-BuLi, N-fluorobenzenesulfonimide at -78℃). Fluoroneplanocin A exhibited 2-fold more potent SAH Inhibitory activity than the parent neplanocin A. A new mechanism of irreversible Inhibition discovered in this work might provide new alternatives in the design of a different class of antiviral agents operating via SAH inhibition.
Jeong, Lak Shin,Lee, Jeong A.,Moon, Hyung Ryong,Kim, Hea Ok,Lee, Kang Man,Lee, Hyun Joo,Chun, Moon Woo MARCEL DEKKER INC 2007 NUCLEOSIDES NUCLEOTIDES AND NUCLEIC ACIDS Vol.26 No.6-7
<P> Novel apio carbocyclic nucleosides 18-21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions.</P>
Jeong, Lak Shin,Moon, Hyung Ryong,Park, Jae Gyu,Shin, Dae Hong,Choi, Won Jun,Lee, Kang Man,Kim, Hea Ok,Chun, Moon Woo,Kim, Hee-Doo,Kim, Joong Hyup 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
Jeong, Lak Shin,Shantanu Pal,Choe, Seung Ah,Choi, Won Jun,Kenneth A. Jacobson,Zhan-Guo Gao,Athena M. Klutz,Xiyan Hou,Kim, Hea Ok,Lee, Hyuk Woo,Lee, Sang Kook,Dilip K. Tosh,Moon, Hyung Ryong 이화여자대학교 약학연구소 2009 藥學硏究論文集 Vol.- No.19
Novel D- and L-4´-thioadenosine derivatives lacking the 4´-hydroxymethyl moiety were synthesized, starting from D-mannose and D-gulonic γ-lactone, respectively, as potent and selective species-independent A₃ adenosine receptor (AR) antagonists. Among the novel 4´-truncated 2-H nucleosides tested, a N^(6)-(3-chlorobenzyl) derivative 7c was the most potent at the human A₃ AR (K_(i) = 1.5 nM), but a N^(6)-(3-bromobenzyl) derivative 7d showed the optimal species-independent binding affinity.
Synthesis and Antiviral Activity of $2^1$-Fluorohexopyranosyl Nucleosides
Jeong, Lak-Shin,Lee, Jong-Eun,Kim, Hea-Ok,Chun, Moon-Woo The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.3
$2^1$-Fluorohexopyranosyl nucleosides 1a and 1b which contained a bioisosteric double bond and a fluorine were synthesized in 12 steps, starting from D-galactose. During diethylaminosulfur trifluoride (DAST) fluorination, retention of stereochemistry was observed through the participation of methoxy or chloro group at the 6-posiition of the purine base. The final nucleosides 1a and 1b were found to be inactive against HIV-1 and HSV-1,2.
Synthesis And Anti-Hcv Activity Of 2''-&bgr;-Hydroxymethylated Nucleosides
Jeong, Lak Shin,Yoo, Byul Nae,Kim, Hea Ok,Lee, Kang Man,Moon, Hyung Ryong Taylor Francis 2007 Nucleosides, nucleotides & nucleic acids Vol.26 No.6
<P> Synthesis of 2' -&bgr;-hydroxymethyl nucleosides 3-6 was accomplished, using stereoselective hydroxymethylation as a key step. Adenine nucleoside 3 showed potent anti-HCV activity, implying that 2' -&bgr;-hydroxymethyl group has the appropriate electronic properties interfering with HCV polymerase.</P>
Synthesis and Antitumor Activity of Fluorocyclopentenyl-Pyrimidines
Jeong, Lak Shin,Zhao, Long Xuan,Choi, Won Jun,Pal, Shantanu,Park, Yeon Hee,Lee, Sang Kook,Chun, Moon Woo,Lee, Young B.,Ahn, Chang Ho,Moon, Hyung Ryong Taylor Francis 2007 NUCLEOSIDES NUCLEOTIDES AND NUCLEIC ACIDS Vol.26 No.6
<P> Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.</P>
Lak Shin, Jeong,In-Young, Choi,Jae-Chul, Lee,Chung, Ju,SunYoung, Hwang,Geum-sil, Cho,Hyuk Woo, Lee,Won Jun, Choi,Won-ki, Kim 梨花女子大學校 藥學硏究所 2012 藥學硏究論文集 Vol.- No.22
A3 adenosine receptor (A3AR) is recognized as a novel therapeutic target for ischemic injury; however, the mechanism underlying anti-ischemic protection by the A3AR agonist remains unclear. Here, we report that 2-chloro-N(6)-(3-iodobenzyl)-5'-N-methylcarbamoyl-4'-thioadenosine (LJ529), a selective A3AR agonist, reduces inflammatory responses that may contribute to ischemic cerebral injury. Postischemic treatment with LJ529 markedly reduced cerebral ischemic injury caused by 1.5-hour middle cerebral artery occlusion, followed by 24-hour reperfusion in rats. This effect was abolished by the simultaneous administration of the A3AR antagonist MRS1523, but not the A2AAR antagonist SCH58261. LJ529 prevented the infiltration/migration of microglia and monocytes occurring after middle cerebral artery occlusion and reperfusion, and also after injection of lipopolysaccharides into the corpus callosum. The reduced migration of microglia by LJ529 could be related with direct inhibition of chemotaxis and down-regulation of spatiotemporal expression of Rho GTPases (including Rac, Cdc42, and Rho), rather than by biologically relevant inhibition of inflammatory cytokine/chemokine release (eg, IL-1β, TNF-α, and MCP-1) or by direct inhibition of excitotoxicity/oxidative stress (not affected by LJ529). The present findings indicate that postischemic activation of A3AR and the resultant reduction of inflammatory response should provide a promising therapeutic strategy for the treatment of ischemic stroke
Development of Biologically Active Nucleosides from Carbohydrate Templates
Lak Shin Jeong 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
Modified nucleosides are regarded as important templates in view of being extensively utilized as biodrugs as well as biological tools. They can be developed as viral and cellular polymerase inhibitors, antimetabolites, or modulators of receptor or enzyme functions. Also after being converted into oligonucleotides, they can be used in studying genome, siRNA, micro RNA, and so on. Especially, they have been used as drugs of choice for the treatment of viral diseases such as AIDS, hepatitis B/C virus (HBV/HCV), and herpetic virus (HSV). Despite of many clinically used drugs, the first generation nucleosides suffer from many drawbacks such as appearance of drug-resistance, toxicity, and metabolic unstability. To solve these problems, we have developed the 2nd generation nucleosides in which furanose oxygen was substituted with sulfur or methylene (CH2), among which several compounds are being developed as antitumor, anti-glaucoma, and anti-inflammatory agents. Recently, we discovered the novel template as next generation nucleosides, 4'-selenonucleosides with various antiviral and antitumor activities. In this symposium, the first, second, and third generation nucleosides developed in our laboratory will be presented in detail.