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RISS 인기검색어
- 검색키워드
- 저자 : Jayvadan Patel (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Fabrication and characterization of liquisolid compacts of Embelin for dissolution enhancement
Komal Parmar,Jayvadan Patel,Navin Sheth 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.5
In the present investigation, an attempt wasmade to improve the dissolution properties of waterinsoluble herbal active ingredient, Embelin (EBN) by utilizingliquisolid technique, which might offer improvedbioavailability. The compacts were prepared using Capryol90 as non-volatile solvent, Neusilin as carrier and Aerosil200 as coating material. Mathematical model and 32 factorialdesign with liquid load factor (X1) and drug concentration(X2) as the independent variables, was utilizedto prepare the liquisolid powder systems. The preparedsystems were subjected for studying micromeritic propertiesand possible drug-excipient interactions by fouriertransform infrared spectroscopy (FTIR), differential scanningcalorimetry (DSC) and powder X-ray diffraction(PXRD). Dissolution studies revealed improvement in thedrug release properties. Physicochemical characterizationof liquisolid compacts by FTIR, DSC and PXRD techniquessuggested reduction in drug crystallinity elaboratingfor the dissolution enhancement. The study reveals thatliquisolid technique is a promising alternative for enhancingdissolution characteristics of EBN.
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Formulation and development of embelin liquisolid systems using quality by design approach
Komal Parmar,Jayvadan Patel,Navin Sheth 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.6
The purpose of the present investigation was to improve dissolution properties of poorly water soluble herbal active ingredient, Embelin (EMB) by formulating liquisolid systems. The new mathematical model was employed for the preparation of the liquisolid systems. Drug loaded liquisolid systems were optimized by utilizing design of experiments (DoE) and principal component analysis (PCA) with carrier-coating ratio (X1) and drug concentration in liquid (X2) as factors. Angle of repose and percentage drug release in 30 min were selected as dependent variables. The liquisolid systems were prepared using Solutol HS-15 in combination of Synperonic PE/ L61 in ratio of 1:1 as non-volatile liquid, Neusilin US2 as carrier and Aerosil 200 as coating material. The relationship between dependent and independent variables were further explicated through regression analysis and response surface plots. Prepared systems were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffraction studies. Invitro dissolution results revealed significant enhancement in drug release properties from the formulations. Physicochemical characterization of liquisolid systems proposed reduction in drug crystallinity which might be ascribed for improvement in dissolution properties. Study demonstrated successful utilization of Solutol HS-15 in combination of Synperonic PE/L61 for dissolution enhancement of EMB.
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Brain targeting efficiency of Curcumin loaded mucoadhesive microemulsion through intranasal route
Snigdha Das Mandal,Surjyanarayan Mandal,Jayvadan Patel 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.2
This study was aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of curcumin through intranasal route. Suitable oil, surfactant and cosurfactant for the development of microemulsion were selected based on maximum curcumin solubility, drug excipients compatibility through FTIR study and non-toxicity to sheep nasal mucosa. Curcumin loaded mucoadhesive microemulsion (CMME) was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (CME) and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain uptake of Curcumin via nasal route was studied by performing biodistribution study in Swiss albino rats. CME was found to be transparent, stable and non ciliotoxic with 57.66 nm ± 3.46, -16.28 mV ± 4.11 and 98.08 % ± 1.01 as average globule size, zeta potential and drug content respectively. PdI and TEM study depicted the narrow size distribution of CME. Following single intranasal administration of CMME and CME at dose of 2.86 mg/kg, Maximum Curcumin uptake in the olfactory bulb was more than 11 fold (51.1 ± 2.8) than that of intravenous injection of Curcumin solution (4.4 ± 1.1). AUC ratio of brain tissues to that in plasma obtained after nasal administration of CMME were significantly higher than those after intravenous administration of Curcumin solution. Findings of the present study revealed that optimal CMME and intranasal route may be considered to be promising and an alternative approach for brain targeting of Curcumin.
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