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- 저자 : J. Meenakshi (검색결과 2 건)
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Patra, Satyajit,Muthuraman, Meenakshi Sundaram,Prabhu, A.T.J. Ram,Priyadharshini, R. Ramya,Parthiban, Sujitha Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Context: In the last half century, discovering, developing and introducing of clinical agents from marine sources have seen great successes, with examples including the anti-cancer compound trabectedin. However, with increasing need for new anticancer drugs, further exploration for novel compounds from marine organism sources is strongly justified. Objective: The major aim of this study was to evaluate the antitumor and antioxidant potential of Sargassum tenerrimum J.Agardh (Sargassaceae) on Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Materials and Methods: An ethanol extract of S. tenerrimum (EEST) from whole algae was used to evaluate cytotoxicity followed by in vivo assessment of toxicity, using biochemical parameters including hepatic and non-hepatic enzymes. Antioxidant properties were examined in animals bearing EAC treated with daily oral administration of 100-300 mg/kg extract suspension. Results: Antitumor effects of EEST in EAC bearing mice was observed with LD50 1815 mg/kg. Parameters like body weight, tumor volume, packed cell volume, tumor cell count, mean survival time and increase in life span in animals in the EAC bearing animals treated with EEST 300 mg/kg was comparable with control group. Significant differences were also seen with changes in total protein content, hepatic enzymes contents, MDA level, and free radical scavenging enzymes in untreated vs. EEST treated group animals. Conclusions: Evaluation of antioxidant enzymes and hepatic enzymes in the EAC animal model treated with EEST exhibited similar effects as the positive control drug 5-flurouracil. S. tenerrimum extracts contain effective antioxidants with significant antitumor activity.
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Analysis and simulation of Matrix Converter Using PSIM
Ashwin Kumar Sahoo,J. Meenakshi,S. S Dash,T. Thyagarajan 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
Matrix Converter, a direct AC/AC Converter replaces the multiple conversion stages and the intermediate energy storage element of the indirect converters by a single power conversion stage, thus being a single stage converter. Matrix Converters employ an array of controlled bidirectional switches as the main power elements to create a variable output voltage system with unrestricted frequency. This paper attempts to give an overview of Matrix Converters and examines the types, features, merits and limitations of such Converters. It presents the basic operating principle of a Single Phase Matrix Converter, Two Phase to Single Phase Matrix Converter, Three Phase to Single Phase Matrix Converter and Three Phase to Three Phase Matrix Converter. The paper also introduces a topology of a Single Phase Matrix Converter , Two Phase to Single Phase Matrix Converter, Three Phase to Single Phase Matrix Converter and Three Phase to Three Phase Matrix Converter in PSIM software environment and analyses the output of the converter for different frequencies. Further, it examines the output voltage of a Single Phase Matrix Converter synthesized using the Sinusoidal Pulse Width Modulation (SPWM) technique. All simulations have been carried out in POWERSIM.
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