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스포츠과학
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Prevalences of lameness in dairy herds in Lower Saxony — investigations as part of the Animal Welfare Plan
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소화계수가 화재진압시간에 미치는 영향 분석
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SELECTED ISSUES OF HYBRID OUTBOARD MOTORS
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Chromosome 13q deletion with Waardenburg syndrome: further evidence for a gene involved in neural crest function on 13q
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Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment
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- 저자 : J. Biela (검색결과 2 건)
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Impact of Power Density Maximization on Efficiency of DC-DC Converter Systems
J.W. Kolar,J. Biela,U. Badstubner 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
The demand for decreasing costs and volume leads to a constantly increasing power density of industrial converter systems. In order to improve the power density further different aspects, like thermal management and electromagnetic effects must be considered in conjunction with the electrical design. Therefore, a comprehensive optimization procedure based on analytical models for minimizing volume of dc-dc converter systems has been developed at the Power Electronic Systems Laboratory of the ETH Zurich. Based on this procedure three converter topologies ? a phase shift converter with current doubler and with capacitive output filter and a series-parallel resonant converter ? are optimized with respect to power density for a telecom supply (400V/48V). There, the characteristic of the power density, the efficiency and the volume distribution between the components as function of frequency is discussed. For the operating points with maximal power density also the loss distribution is presented. Furthermore, the sensitivity of the optimum with respect to junction temperature, cooling and core material is investigated. The highest power density is achieved by the series-parallel resonant converter. For a 5 ㎾ supply a density of approximately 12 ㎾/ltr. and a switching frequency of ca. 130 ㎑ results.
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Baek, S.,Kerjan, G.,Bielas, Stephanie L.,Lee, J.,Fenstermaker, Ali G.,Novarino, G.,Gleeson, Joseph G. Cell Press 2014 Neuron Vol.82 No.6
Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortical neuronal migration phenotype. Here we report that in utero electroporation of shRNA, but not siRNA or miRNA, to Dcx demonstrates a migration phenotype in Dcx knockouts akin to the effect in wild-type mice, suggesting shRNA-mediated off-target toxicity. This effect was not limited to Dcx, as it was observed in Dclk1 knockouts, as well as with a fraction of scrambled shRNAs, suggesting a sequence-dependent but not sequence-specific effect. Profiling RNAs from electroporated cells showed a defect in endogenous let7 miRNA levels, and disruption of let7 or Dicer recapitulated the migration defect. The results suggest that shRNA-mediated knockdown can produce untoward migration effects by altering endogenous miRNA pathways.
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