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Itokawa, Hideji The Plant Resources Society of Korea 1993 한국자원식물학회지 Vol.6 No.1
To data, many types of compounds having antineoplastic activity have been isolated from higher plants, that is, alkalodids, terpenes, lignans, steroids and so on. Some of ther were isolated from Indonesian plants, Curcuma xanthorrhiza and Eurycoma longifolia. Bisaborane type compounds were compounds were isolated as antimeoplastic compounds againest Sarcoma 180A from C. xanthorrhiza, and quassinoids and euryrene type triterpenes from triterpenes from El longifolia. Casearines, a kind of diterpene, had been isolated as cytotxic components from Casearia sylvestris distributed in South America. RA series Cyclic hexapeptides isolated from Rubia akane and R. cordifolia also have strong antineoplastic activity against various types of tumors. Till now, 16 kinds of RA series compounds were isolated and named as RA-I~XVI. Moreover, monoglucoside of RA-V newly isolated from same plant. Many kinds of derivatives including natural RA compounds were tested for QSAR, and one of them, RA-VII was screened up as a most suitable substance as an antitumor agent. RA-VII(=RA 700) has strong cytotoxic activity against KB cells, P388 lymphocytic leukemia and MM2 mammary carcinoma cells. In some solution, three conformers of RA-VII were observed by NMR. It was discussed the relationship between conformation and activity. Total synthesis was already completed, but there is left room for improvement. Phase I clinical trials for RA-VII has been finished, then Phase II trials will be started before long.
Antitumor Substances from Higher Plants in Asian Region
Itokawa Hideji,Takeya Koichi 한국자원식물학회 1996 한국자원식물학회 학술심포지엄 Vol.1996 No.-
In this review, we summarize the isolation, structural determination, antitumor activity of substances from higher plants which were collected in Asian region.
Hideji Itokawa,Kouji Matsumoto,Hiroshi Morita,Koichi Takeya 한국자원식물학회 1994 한국자원식물학회지 Vol.7 No.1
Antileukemic tropoloisoquinoline alkaloids, pareirubine A (1) and gandirubrine (2), at first have been isolated from.Abuta concolor (Menisper-maceae). Methylation of 1 and 2, existing in solution as a mixture of tautomersgave the corresponding four methyl derivatives (3 -6). Thioimerubrine (7) andthioisoimerubrine (8) were prepared by the nucleophilic substitutions of themethoxyl groups at C-11 and -10, respectively. Acetylation of 1 and 2produced the corresponding mono-acetyl tautomers (9 and 10). Antileukemicactivity of these derived tropoloisoquinoline alkaloids is also reported.
Cangorins F-J , Five Additional Oligo-Nicotinated Sesquiterpene Polyesters from Maytenus Ilicifolia
Hideji Itokawa,Osamu Shirota,Hiroshi Morita,Koichi Takeya,Yoichi Iitaka 한국자원식물학회 1994 한국자원식물학회지 Vol.7 No.1
The isolation and structure elucidation Of five new oligo-nicotinated sesquiterpene polyesters with a dihydroagarofuran core from Maytenus ilicifolia, named cangorins F, G,H,1 and J [1-5], is described. The strurtures of these compounds, which possessed nicotinyl,benroyl, and areryl groups as esterifying moieties, were elucidaied by $^IH- and ^{13}C$ 수식 이미지-nmrspectroscopic studies, inrlusive of hereronuclear correlation, long-range correlation, and nOespectra, along with mass and cd spectral dara, and the X-ray crystallographic analysis of 1.
C18 and C19 Quassinoids from Eurycoma longifolia
Hideji Itokawa,Xu-Rong Qin,Hiroshi Morita,Koichi Takeya 한국자원식물학회 1994 한국자원식물학회지 Vol.7 No.1
Two new 1,2-seco-1-nor-6((5 $\mapsto$ 수식 이미지 10)abeo-picrasan-2,5-olideskeleton quassinoids, eurylactones A [1] and B [2], and two new $C_{19}$ skeleton quassinoids 3 and 4 were isolated from Eurycoma longifolia together with two known $C_{18}$ quassinoids 5 and 6. Their sttuctures were established by the spectral evidence.Many quassinoids have already been isolated (1-3) from the roots, wood, and leaves of Eurycoma longiolia Jack (Simaroubaceae) and have been used as a folk medicine insoutheast Asia. As part of a series of studies, we have further undertaken the chemicalinvestigation of the n-BuOH-soluble fraction of the MeOH extract and isolated two new1,2-seco-1-nor-6(5 $\mapsto$ 수식 이미지 10)abeo-picrasane skeleton quassinoids 1 and 2, which have beenknown only in shinjulactone B (4,5) and yadanfiolide (6), two new $C_{19}$ 수식 이미지-type quasslnolds3 and 4, and two known C18-type quassinoids 5 and 6. In this paper, the structureelucidation and biosenetic relation of these compounds are described.
Antitumor Substances from Higher Plants in Asian Region
Hideji Itokawa,Koichi Takeya 한국자원식물학회 1995 한국자원식물학회지 Vol.8 No.3
In this review, we summarize the isolation, structural determination, antitumor activity of substances from higher plants which were collected in Asian region.