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Casati, S.,Aschberger, K.,Barroso, J.,Casey, W.,Delgado, I.,Kim, T. S.,Kleinstreuer, N.,Kojima, H.,Lee, J. K.,Lowit, A.,Park, H. K.,Ré,gimbald-Krnel, M. J.,Strickland, J.,Whelan, M.,Yang, Y.,Zua Springer Berlin Heidelberg 2018 Archives of toxicology Vol.92 No.2
<P>Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of the skin sensitisation adverse outcome pathway. Nevertheless, the currently adopted methods, when used in isolation, are not sufficient to fulfil regulatory requirements on the skin sensitisation potential and potency of chemicals comparable to that provided by the regulatory animal tests. For this reason, a number of defined approaches integrating data from these methods with other relevant information have been proposed and documented by the OECD. With the aim to further enhance regulatory consideration and adoption of defined approaches, the European Union Reference Laboratory for Alternatives to Animal testing in collaboration with the International Cooperation on Alternative Test Methods hosted, on 4–5 October 2016, a workshop on the international regulatory applicability and acceptance of alternative non-animal approaches, i.e., defined approaches, to skin sensitisation assessment of chemicals used in a variety of sectors. The workshop convened representatives from more than 20 regulatory authorities from the European Union, United States, Canada, Japan, South Korea, Brazil and China. There was a general consensus among the workshop participants that to maximise global regulatory acceptance of data generated with defined approaches, international harmonisation and standardisation are needed. Potential assessment criteria were defined for a systematic evaluation of existing defined approaches that would facilitate their translation into international standards, e.g., into a performance-based Test Guideline. Informed by the discussions at the workshop, the ICATM members propose practical ways to further promote the regulatory use and facilitate adoption of defined approaches for skin sensitisation assessments.</P>
COMBUSTION INSTABILITIES AND NANOPARTICLES EMISSION FLUCTUATIONS IN GDI SPARK IGNITION ENGINE
A. E. HASSANEEN,S. SAMUEL,I. WHELAN 한국자동차공학회 2011 International journal of automotive technology Vol.12 No.6
The main challenge facing the concept of gasoline direct injection is the unfavourable physical conditions at which the premixed charge is prepared and burned. These conditions include the short time available for gasoline to be sprayed, evaporated, and homogeneously mixed with air. These conditions most probably affect the combustion process and the cycle-by-cycle variation and may be reflected in overall engine operation. The aim of this research is to analyze the combustion characteristics and cycle-by-cycle variation including engine-out nanoparticulates of a turbocharged, gasoline direct injected spark ignition (DISI) engine at a wide range of operating conditions. Gasoline DISI, turbo-intercooled, 1.6L, 4 cylinder engine has been used in the study. In-cylinder pressure has been measured using spark plug mounted piezoelectric transducer along with a PC based data acquisition. A single zone heat release model has been used to analyze the in-cylinder pressure data. The analysis of the combustion characteristics includes the flame development (0-10% burned mass fraction) and rapid burn (10-90% burned mass fraction) durations at different engine conditions. The cycle-by-cycle variations have been characterized by the coefficient of variations (COV) in the peak cylinder pressure, the indicated mean effective pressure (IMEP), burn durations, and particle number density. The combustion characteristics and cyclic variability of the DISI engine are compared with data from throttle body injected (TBI) engine and conclusions are developed.