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Fayyaz, Hassan,Shah, Abdullah Korean Mathematical Society 2018 대한수학회보 Vol.55 No.3
This article deals with implementation of a high-order finite difference scheme for numerical solution of the incompressible Navier-Stokes equations on curvilinear grids. The numerical scheme is based on pseudo-compressibility approach. A fifth-order upwind compact scheme is used to approximate the inviscid fluxes while the discretization of metric and viscous terms is accomplished using sixth-order central compact scheme. An implicit Euler method is used for discretization of the pseudo-time derivative to obtain the steady-state solution. The resulting block tridiagonal matrix system is solved by approximate factorization based alternating direction implicit scheme (AF-ADI) which consists of an alternate sweep in each direction for every pseudo-time step. The convergence and efficiency of the method are evaluated by solving some 2D benchmark problems. Finally, computed results are compared with numerical results in the literature and a good agreement is observed.
Hassan Fayyaz,Abdullah Shah 대한수학회 2018 대한수학회보 Vol.55 No.3
This article deals with implementation of a high-order finite difference scheme for numerical solution of the incompressible Navier-Stokes equations on curvilinear grids. The numerical scheme is based on pseudo-compressibility approach. A fifth-order upwind compact scheme is used to approximate the inviscid fluxes while the discretization of metric and viscous terms is accomplished using sixth-order central compact scheme. An implicit Euler method is used for discretization of the pseudo-time derivative to obtain the steady-state solution. The resulting block tridiagonal matrix system is solved by approximate factorization based alternating direction implicit scheme (AF-ADI) which consists of an alternate sweep in each direction for every pseudo-time step. The convergence and efficiency of the method are evaluated by solving some 2D benchmark problems. Finally, computed results are compared with numerical results in the literature and a good agreement is observed.
TRAIL Mediated Signaling in Pancreatic Cancer
Nogueira, Daniele Rubert,Yaylim, Ilhan,Aamir, Qurratulain,Kahraman, OzlemTimirci,Fayyaz, Sundas,Naqvi, Syed Kamran-Ul-Hassan,Farooqi, Ammad Ahmad Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Research over the years has progressively shown substantial broadening of the tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)-mediated signaling landscape. Increasingly it is being realized that pancreatic cancer is a multifaceted and genomically complex disease. Suppression of tumor suppressors, overexpression of oncogenes, epigenetic silencing, and loss of apoptosis are some of the extensively studied underlying mechanisms. Rapidly accumulating in vitro and in vivo evidence has started to shed light on the resistance mechanisms in pancreatic cancer cells. More interestingly a recent research has opened new horizons of miRNA regulation by DR5 in pancreatic cancer cells. It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7. Xenografting DR5 silenced pancreatic cancer cells in SCID-mice indicated that there was notable suppression of tumor growth. There is a paradigm shift in our current understanding of TRAIL mediated signaling in pancreatic cancer cells that is now adding new layers of concepts into the existing scientific evidence. In this review we have attempted to provide an overview of recent advances in TRAIL mediated signaling in pancreatic cancer as evidenced by findings of in vitro and in vivo analyses. Furthermore, we discuss nanotechnological advances with emphasis on PEG-TRAIL and four-arm PEG cross-linked hyaluronic acid (HA) hydrogels to improve availability of TRAIL at target sites.
Anticancer Activity of Essential Oils: Targeting of Protein Networks in Cancer Cells
Aras, Aliye,Iqbal, Muhammed Javed,Naqvi, Syed Kamran-Ul-Hassan,Gercek, Yusuf Can,Boztas, Kadir,Gasparri, Maria Luisa,Shatynska-Mytsyk, Iryna,Fayyaz, Sundas,Farooqi, Ammad Ahmad Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Cancer is a multifaceted and genomically complex disease and research over decades has gradually and sequentially shown that essential biological mechanisms including cell cycle arrest and apoptosis are deregulated. The benefits of essential oils from different plants have started to gain appreciation as evidenced by data obtained from cancer cell lines and xenografted mice. Encouraging results obtained from preclinical studies have attracted considerable attention and various phytochemicals have entered into clinical trials.