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      • Anti-Heat Shock Protein-27 Antibody Levels in Women with Breast Cancer: Association with Disease Complications and Two-Year Disease-Free Survival

        Homaei-Shandiz, Fatemeh,Mehrad-Majd, Hassan,Tasbandi, Mojtaba,Aledavood, Amir,Afshari, Jalil Tavakol,Ghavami, Vahid,Ghayour-Mobarhan, Majid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10

        Background and Aim: Breast cancer is a major healthcare problem in women. There are many reports about up-regulation of Hsp27 in cancer tissues but less is known about the potential relationship between Hsp27 antibody levels and breast cancer complications. We here investigated concentrations of serum Hsp27 antigen and antibodies in subjects with and without breast cancer and assessed potential associations with two-year disease-free survival, histological grade and number of lymph nodes. Materials and Methods: Specifically, serum Hsp27 antigen and antibody levels from 97 patients with breast cancer, and 65 healthy controls were determined by enzyme-linkedimmunosorbent assays (ELISAs). Results: Serum Hsp27 and antibody levels were significantly (p<0.001) higher in patients with breast cancer compared to the control group, but no relationship were found with two-year disease free survival, histological grade or number of lymph nodes (p> 0.6, 0.2 and 0.9 respectively). Conclusions: Elevated levels of Hsp27 antibody occur with women with breast cancer but do not appear to be associated with the presence of disease clinical complications.

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        Aeroelastic analysis of cantilever non-symmetric FG sandwich plates under yawed supersonic flow

        Mohammad Hosseini,Ali Ghorbanpour Arani,Mohammad Reza Karamizadeh,Hassan Afshari,Shahriar Niknejad 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.6

        In this paper, a numerical solution is presented for supersonic flutter analysis of cantilever non-symmetric functionally graded (FG) sandwich plates. The plate is considered to be composed of two different functionally graded face sheets and an isotropic homogeneous core made of ceramic. Based on the first order shear deformation theory (FSDT) and linear piston theory, the set of governing equations and boundary conditions are derived. Dimensionless form of the governing equations and boundary conditions are derived and solved numerically using generalized differential quadrature method (GDQM) and critical velocity and flutter frequencies are calculated. For various values of the yaw angle, effect of different parameters like aspect ratio, thickness of the plate, power law indices and thickness of the core on the flutter boundaries are investigated. Numerical examples show that wings and tail fins with larger length and shorter width are more stable in supersonic flights. It is concluded for FG sandwich plates made of Al-Al2O3 that increase in volume fraction of ceramic (Al2O3) increases aeroelastic stability of the plate. Presented study confirms that improvement of aeroelastic behavior and weight of wings and tail fins of aircrafts are not consistent items. It is shown that value of the critical yaw angle depends on aspect ratio of the plate and other parameters including thickness and variation of properties have no considerable effect on it. Results of this paper can be used in design and analysis of wing and tail fin of supersonic airplanes.

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