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RISS 인기검색어
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- 저자 : Hamid Mohammadjafari (검색결과 1 건)
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Hamid Mohammadjafari,Alireza Rafiei,Seyed Abdollah Mousavi,Abdulrasool Alaee,Yalda Yeganeh 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.10
Purpose: Antenatal hydronephrosis (AH) is found in 0.5%–1% of neonates. The aim ofthe study was to assess the urinary concentrations of 3 biomarkers, endothelin-1 (ET-1),monocyte chemotactic peptide-1 (MCP-1), and N-acetyl-glucosaminidase (NAG) in severelyhydronephrotic neonates. Materials and Methods: Neonates with a history of prenatal hydronephrosis were enrolledin the prospective study in 2 groups. Group 1 included neonates with severe formsof obstruction requiring surgical intervention and group 2 included neonates with milderforms of obstruction without any functional impairment. Fresh voided urinary levelsof ET-1, MCP-1, and NAG were measured and their ratios to urinary Cr were calculated. Results: Fourty-two neonates were enrolled into the 2 groups: group 1, 24 patients (21male, 3 female); group 2, 18 neonates (16 male, 2 female). There were no statisticallysignificant differences between urinary ET-1, NAG, MCP-1 values, and ET-1/Cr andNAG/Cr ratios in groups 1 and 2. The urinary MCP-1/Cr ratio was significantly higherin group 1 than in group 2. For comparison of groups 1 and 2, the cut-off values weremeasured as 0.5709 ng/mg (sensitivity, 75%; specificity, 67%; positive predictive value[PPV], 71%; negative predictive value [NPV], 71%), 0.927 ng/mg (sensitivity, 77%; specificity,72%; PPV, 77%; NPV, 72%), and 1.1913 IU/mg (sensitivity, 62%; specificity,67%; PPV, 68%; NPV, 60%) for ET-1/Cr, MCP-1/Cr, and NAG/Cr ratios, respectively. Conclusions: The urinary MCP-1/Cr ratio is significantly elevated in neonates with severeobstruction requiring surgical intervention. Based upon these results, urinaryMCP-1/Cr may be useful in identification of severe obstructive hydronephrosis inneonates.
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