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Hagel, Christian,Treszl, Andr?s,Fehlert, Julia,Harder, Jonas,von Haxthausen, Franziska,Kern, Meike,von Bueren, Andr? O,Kordes, Uwe M. Nijhoff ; Kluwer Academic Publishers 2013 Journal of neuro-oncology Vol.112 No.2
<P>Ependymomas comprise 8 % of all intracranial tumors in children <15 years. Recent studies revealed that some supratentorial ependymomas express neuronal antigens and that high expression of neurofilament protein light polypeptide (NEFL) correlates with better clinical outcome. We retrospectively analyzed an expanded panel of proteins in 6 supratentorial, 15 posterior fossa and 4 spinal pediatric ependymomas by immunohistochemistry. Expression of high and low affinity neurotrophin receptors TrkA (NTRK1) and p75 (NGFR), pan-neuronal markers NeuN (RBFOX3) and synaptophysin, radial glial marker SOX9, adhesion molecules CD56 (NCAM) and CD44, junctional protein connexin 43 (GJA1), glial fibrillary acidic protein (GFAP), epithelial membrane antigen and proliferation associated antigen Ki-67 were evaluated in a semi-quantitative or quantitative (Ki-67 and NeuN-index) fashion. We found p75 and NeuN to be expressed at significantly higher levels in supratentorial versus infratentorial tumors and GFAP to be expressed at significantly higher levels in infratentorial lesions. In conclusion, immunohistochemical expression of p75, NeuN and GFAP differed in ependymomas depending on tumor topography supporting the view of divergent cells of origin. However, because of the small sample size the results are of preliminary nature and replication in a larger cohort would be desirable.</P>
The BRAHMS Experiment at the Relativistic Heavy Ion Collider
Y. K. Lee,I. G. Bearden,D. Beavis,C. Besliu,Y. Blyakhman,J. Brzychczyk,B. Budick,H. Bggild,C. Chasman,C. H. Christensen,P. Christiansen,J. Cibor,R. Debbe,E. Enger,J. J. Gaardhje,K. Grotowski,K. Hagel 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.I
The BRAHMS probes the hot and dense nuclear matter at the RHIC which has reached its design energy of psNN = 200 GeV for Au + Au collisions. The BRAHMS uses magnetic spectrometers for hadrons covering a large phase space 0 < y < 4 with good particle identification and momentum resolution. A comprehensive investigation of multiplicity distributions of emitted charged particles is carried out. Ratios of yields of antiparticles to particles are also measured as a function of rapidity. Rapidity dependent net-proton yield indicates that substantial transparency has been achieved in these collisions. Transverse momentum spectra of charged hadrons are measured up to 5 GeV/c which indicates a significant medium eect when compared to nucleon + nucleon reference spectra.