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- 저자 : Geshi, N. (검색결과 5 건)
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Expression and functional role of Sox9 in keratinocyte differentiation
Ge Shi,Kyung Cheol Sohn,Dae Kyoung Choi,Young Lee,Chang Deok Kim,Young Joon Seo,Jeung Hoon Lee 한국피부장벽학회 2009 한국피부장벽학회지 Vol.11 No.2
Sox9 (SRY (sex determining region Y)-box 9) is an autosomal gene involved in the control of the male-determining pathway. It has been known that Sox9 is expressed in outer root sheath of hair follicle and exerts its action as an importance regulator in maintenance of stemness for hair cells. However, its expression and putative role in epidermal keratinocytes has not been well elucidated yet. In this study, we examined the expression and functional role of Sox9 in keratinocyte differentiation. Immunohistochemical staining showed that Sox9 is predominantly expressed in basal layer. Consistent with this result, Sox9 mRNA level was markedly decreased by the calcium treatment of cultured keratinocytes. And, Western blot also showed that the protein level for Sox9 was decreased by calcium in a temporal manner. To investigate its putative role, we made a recombinant adenovirus harboring the expression cassette for Sox9. Overexpression of Sox9 prevented calcium-induced loricin and involucrin expression. Consistent with, overexpression of Sox9 decreased the promoter activities of involucrin and loricrin. In addition, Sox9 overexpression resulted in significant down-regulation of the cell cycle-related genes p21. Interestingly, Sox9 expression was highly increased in several skin diseases such as psoriasis, BCC and SCC. Together, these results suggest that Sox9 is an important regulator for keratinocyte proliferation and differentiation, and may have related with many of skin diseases that are characterized by the hyperproliferative potential of keratinocytes.
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Nanocommunication Design in Graduate-Level Education and Research Training
Itoh, Tadashi,Akai, Hisazumi,Takeda, Seiji,Ogawa, Hisahito,Ichikawa, Satoshi,Geshi, Masaaki,Ara, Masato,Niioka, Hirohiko The Korean Vacuum Society 2010 Applied Science and Convergence Technology Vol.19 No.6
나노과학, 나노공학, 및 나노기술의 축적된 지식을 대중참여라는 관점을 첨가하여 대학원생이나 젊은 과학자들에게 가르치기 위하여, 오사카 대학은 2004년부터 다양한 교육 및 훈련 프로그램을 제공하고 있는데, 교학문적(交學問的) 대학원 부전공 과목, 야간 강좌, 단기 국제훈련 프로그램 등이다. 연속강의는 위성통신을 이용하여 교실에 전달되기도 한다. 또한 학생들은 현대시설을 활용한 실습을 통하여 직접, 나노소재와 나노소자를 설계, 제작, 측정, 특성분석 및 기능화 할 수 있다. 그리고 특별히 사회적, 법적, 윤리적 관계를 포함하는 나노소통에 관한 연구훈련 프로그램과 강좌 시리즈가 네 개 개설되어 있으니, "나노기술 경력 건설 강좌", "나노기술의 대중 참여", "나노기술 지도 설계", "목적과제 학습 및 훈련 프로그램(PAL)"이다. 전체 프로그램의 윤곽이 나노소통 특별 프로그램과 함께 소개되어 있다. In order to teach the accumulated knowledge of nanoscience, nanoengineering and nanotechnology to graduate school students and young scientists with the sense of public engagement, Osaka University started from 2004 to prepare and offer various kinds of education and training programs such as trans-disciplinary graduate-school minor program, evening course refresher program, short-term international research training program, etc. It offers a series of lectures, partly broadcasted live to satellite classrooms. In addition, the students can join intensive hands-on training programs using modern facilities, allowing them to design, fabricate, measure, characterize and functionalize nanomaterials and nanodevices. In addition, there are four specially designed lectures and research training programs aimed for nanocommunication including social, legal and ethical relationship: "Nanotechnology Career-up Lectures", "Social Engagement on Nanotechnology", "Road Map Design on Nanotechnology", and "Project-Aimed Learning and Training Programs (PAL)". The outline of the whole programs is described together with the specialized programs for nanocommunication.
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Nanocommunication Design in Graduate-Level Education and Research Training
Tadashi Itoh,Hisazumi Akai,Seiji Takeda,Hisahito Ogawa,Satoshi Ichikawa,Masaaki Geshi,Masato Ara,Hirohiko Niioka 한국진공학회 2010 Applied Science and Convergence Technology Vol.19 No.6
In order to teach the accumulated knowledge of nanoscience, nanoengineering and nanotechnology to graduate school students and young scientists with the sense of public engagement, Osaka University started from 2004 to prepare and offer various kinds of education and training programs such as trans-disciplinary graduate-school minor program, evening course refresher program, short-term international research training program, etc. It offers a series of lectures, partly broadcasted live to satellite classrooms. In addition, the students can join intensive hands-on training programs using modern facilities, allowing them to design, fabricate, measure, characterize and functionalize nanomaterials and nanodevices. In addition, there are four specially designed lectures and research training programs aimed for nanocommunication including social, legal and ethical relationship: “Nanotechnology Career-up Lectures”, “Social Engagement on Nanotechnology”, “Road Map Design on Nanotechnology”, and “Project- Aimed Learning and Training Programs (PAL)”. The outline of the whole programs is described together with the specialized programs for nanocommunication.
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Utilization of L-camitine to Improve Cryo-Tolerance of Bovine Oocytes and Embryos
Tamas SOMFAI,Yasushi INABA,Toshikiyo TAKAHASHI,Vibuntita CHANKITISAKUL,Masahiro KANEDA,Satoshi AKAel,Shinya WATANABE,Seiki HARAGUCHI,Satoko MATOBA,Masaya GESHI,Takashi NAGAI 한국동물생명공학회(구 한국동물번식학회) 2012 발생공학 국제심포지엄 및 학술대회 Vol.2012 No.1
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Cho, S. K.,Ryu, M. Y.,Poulsen, C.,Kim, J. H.,Oh, T. R.,Choi, S. W.,Kim, M.,Yang, J. Y.,Boo, K. H.,Geshi, N. Elsevier Science B.V., Amsterdam. 2017 FEBS letters Vol.591 No.10
<P>A highly coordinated complex known as the microprocessor precisely processes primary transcripts of MIRNA genes into mature miRNAs. In plants, the microprocessor minimally consists of three components: Dicer-like protein 1 (DCL1), HYPONASTIC LEAF 1 (HYL1), and SERRATE (SE). To precisely modulate miRNA maturation, the microprocessor cooperates with at least 12 proteins in plants. In addition, we here show the involvement of a novel gene, HYL1-interacting GIY-YIG-like endonuclease (HIGLE). The encoded protein has a GIY-YIG domain that is generally found within a class of homing endonucleases. HIGLE directly interacts with the microprocessor components HYL1 and SE. Unlike the functions of other GIY-YIG endonucleases, the catalytic core of HIGLE has both DNase and RNase activities that sufficiently processes miRNA precursors into short fragments in vitro.</P>
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