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EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma.
Lee, Jeong-Won,Han, Hee Dong,Shahzad, Mian M K,Kim, Seung Wook,Mangala, Lingegowda S,Nick, Alpa M,Lu, Chunhua,Langley, Robert R,Schmandt, Rosemarie,Kim, Hye-Sun,Mao, Shenlan,Gooya, John,Fazenbaker, Ch U.S. Dept. of Health, Education, and Welfare, Publ 2009 Journal of the National Cancer Institute Vol.101 No.17
<P>EphA2 is overexpressed in many types of human cancer but is absent or expressed at low levels in normal epithelial tissues. We investigated whether a novel immunoconjugate containing an anti-EphA2 monoclonal antibody (1C1) linked to a chemotherapeutic agent (monomethyl auristatin phenylalanine [MMAF]) through a noncleavable linker maleimidocaproyl (mc) had antitumor activity against ovarian cancer cell lines and tumor models.</P>