http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
오늘 본 자료
-
NNO01 Evidence of thalamocortical fibers maturation in early human brain development assessed by diffusion tensor imaging
-
Experimental and numerical studies on erosion damage in damping holes on the valve plate of an axial piston pump
-
지상발표 : 간 질환의 면역 globulin 에 대한 연구
-
소형 브러시리스 DC 전동기의 토크 특성 향상을 위한 최적 구동법에 관한 연구
-
Amphiphilic photo-induced triblock polyoxazoline through coumarin dimerization: Efficient synthetic tool for nanoparticles
- 검색키워드
- 저자 : Chantal M. Longo-Guess (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Chankyu Park,William Falls,Jacqueline H. Edgar,Chantal M. Longo-Guess,Susan L. Ackerman 한국실험동물학회 2001 한국실험동물학회 학술발표대회 논문집 Vol.2001 No.-
Positional cloning (map-based cloning) of mutations or genetic variations has been served as an invaluable tool to understand in vivo functions of genes and to identify molecular components underlying phenotypes of interest. Mice homozygous for the cerebellar deficient folia (cdf) mutation are ataxic, with cerebellar hypoplasia and abnormal lobulation of the cerebellum. In the cdf mutant cerebellum approximately 40% of Purkinje cells are ectopically located within the white matter and the inner granule cell layer (IGL). To identify the cdf gene, a high-resolution genetic map for the cdf-gene-encompassing region was constructed using 1997 F2 mice generated from C3H/HeSnJ-cdf/cdf and CAST/Ei intercross. The cdf gene showed complete linkage disequilibrium with three tightly linked markers D6Mit208, D6Mit359, and D6Mit225. A contig using YAC, BAC, and P1 clones was constructed for the cdf critical region to identify the gene. We have identified a deletion in the cdf critical region on Chromosome 6 that removes approximately 150 kb of DNA, including an exon encoding a portion of the actin-binding domain of N-catenin, the protein that links the classical cadherins to the neuronal cytoskeleton. Normal cerebellar and hippocampal morphology was restored in cdf mutant mice expressing an N-catenin cDNA transgene, demonstrating that the catenin/cadherin cell adhesion complexes play an important role in the lamination of the cerebellum and hippocampus. Furthermore, our analysis of mutant mice demonstrates that fear conditioning, a form of associative learning, and prepulse inhibition are disrupted in cdf mutant mice, implicating the involvement of catenin/cadherin complexes in these behavioral processes.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
