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Chakrasali, Prashant,Kim, Kyuneun,Jung, Young-Sik,Kim, Hyejin,Han, Soo Bong American Chemical Society 2018 ORGANIC LETTERS Vol.20 No.23
<P>Herein, a one-step chlorosulfonylation of alkynes via a photocatalytic redox process is described. A variety of commercially available sulfonyl chlorides can be applied for the generation of sulfonyl radical species under visible-light irradiation. Regio- and stereoselective addition of the sulfonyl radical and chloride leads to the efficient formation of (<I>E</I>)-selective β-chlorovinyl sulfones from a broad range of terminal and internal alkynes. The reported method represents an operationally simple and mild way to furnish vinyl sulfones.</P> [FIG OMISSION]</BR>
Kim, Saegun,Chakrasali, Prashant,Suh, Hyo Sun,Mishra, Neeraj Kumar,Kim, Taeyoung,Han, Sang Hoon,Kim, Hyung Sik,Lee, Byung Mu,Han, Soo Bong,Kim, In Su American Chemical Society 2017 Journal of organic chemistry Vol.82 No.14
<P>The aldimine-directed C-H amidation of various arenes with N-acyl azides as amidation surrogates under cationic iridium(III) catalysis is described. This transformation efficiently provides a range of 2-aminobenzaldehyde derivatives with excellent site selectivity and functional group compatibility. The resulting 2-aminobenzaldehyde framework provides facile access to a range of biologically interesting heterocycles. In addition, all synthetic compounds were screened for anti-inflammatory activity against interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) with lipopolysaccharide (LPS)-induced RAW264.7 cells. Generally, a range of ortho-amidated benzaldehydes displayed promising inhibitory activity against IL-1 beta and TNF-alpha compared to dexamethasone as a positive control. Notably, compounds (3ae and 4ac) were found to exhibit potent anti-inflammatory activity stronger than that of dexamethasone.</P>