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Bülent Çetinel,Bulent Onal 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.12
Purpose: Central nervous system (CNS) and cardiovascular system (CVS) side effects of anticholinergic agents used to treat overactive bladder (OAB) are underreported. Hence, this review aimed to focus on the mechanisms of CNS and CVS side effects of anticholinergic drugs used in OAB treatment, which may help urologists in planning the rationale for OAB treatment. Materials and Methods: PubMed/MEDLINE was searched for the key words “OAB,” “anticholinergics,” “muscarinic receptor selectivity,” “blood-brain barrier,” “CNS,” and “CVS side effects.” Additional relevant literature was determined by examining the reference lists of articles identified through the search. Results: CNS and CVS side effects, pharmacodynamic and pharmacokinetic properties, the metabolism of these drugs, and the clinical implications for their use in OAB are presented and discussed in this review. Conclusions: Trospium, 5-hydroxymethyl tolterodine, darifenacin, and solifenacin seem to have favorable pharmacodynamic and pharmacokinetic properties with regard to CNS side effects, whereas the pharmacodynamic features of darifenacin, solifenacin, and oxybutynin appear to have an advantage over the other anticholinergic agents (tolterodine, fesoterodine, propiverine, and trospium) with regard to CVS side effects. To determine the real-life situation, head-to-head studies focusing especially on CNS and CVS side effects of OAB anticholinergic agents are urgently needed.
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Giant Multilocular Cystadenoma of the Prostate: A Rare Cause of Huge Cystic Pelvic Mass
Deniz Cebi Olgun,Bulent Onal,Ismail Mihmanli,Fatih Kantarci,Haydar Durak,Hale Demir,Bulent Cetinel1 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.3
Giant multilocular prostatic cystadenoma is a rare benign tumor that evolves from the prostate gland. Obstructive voiding symptoms occur in all reported cases. These lesions do not invade adjacent structures. Preoperative radiologic evaluation can define the benign nature of the lesion. Here we report a case of large cystic lesions identified by magnetic resonance imaging and sonographic findings that caused an extensive mass effect in the pelvis. When retrovesical, huge cystic lesions fill the pelvis completely in young men, with high levels of serum prostate-specific antigen, giant multilocular prostatic cystadenoma should be considered as a differential diagnosis. To our knowledge, this is the youngest case of prostatic cystadenoma reported in the literature.
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