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RISS 인기검색어
- 검색키워드
- 저자 : Buchwald, Dedra (검색결과 3 건)
- 무료
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- 유료
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International Network of Twin Registries (INTR): Building a Platform for International Collaboration
Buchwald, Dedra,Kaprio, Jaakko,Hopper, John L.,Sung, Joohon,Goldberg, Jack,Fortier, Isabel,Busjhan, Andreas,Sumathipala, Athula,Cozen, Wendy,Mack, Thomas,Craig, Jeffrey M.,Harris, Jennifer R. Cambridge University Press 2014 TWIN RESEARCH AND HUMAN GENETICS - Vol.17 No.6
<P>The International Network of Twin Registries (INTR) aims to foster scientific collaboration and promote twin research on a global scale by working to expand the resources of twin registries around the world and make them available to researchers who adhere to established guidelines for international collaboration. Our vision is to create an unprecedented scientific network of twin registries that will advance knowledge in ways that are impossible for individual registries, and includes the harmonization of data. INTR will also promote a broad range of activities, including the development of a website, formulation of data harmonization protocols, creation of a library of software tools for twin studies, design of a search engine to identify research partners, establishment of searchable inventories of data and biospecimens, development of templates for informed consent and data sharing, organization of symposia at International Society of Twin Studies conferences, support for scholar exchanges, and writing grant proposals.</P>
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Front-end investigations of the coated particles of nuclear fuel samples –ion polishing method
Zuzanna M. Krajewska,Tomasz Buchwald,Tomasz Tokarski,Wacław Gudowski 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
The investigations of the coated-particles of nuclear fuel samples are carried out in three stages: frontend, irradiation in the reactor core, and post-irradiation examination. The front-end stage is the initialanalysis of the failures rates of produced samples before they are placed in the reactor core. The purposeof the verification is to prepare the particles for an experiment that will determine the degree of damageto the coated particles at each stage. Before starting experiments with the samples, they must beproperly prepared. Polishing the samples in order to uncover the inner layers is an important, initialexperimental step. The authors of this paper used a novel way to prepare samples for testing - byapplying an ion polisher. Mechanical polishing used frequently for sample preparations generatesadditional mechanical damages in the studied fuel particle, thus directly affecting the experimentalresults. The polishing methods were compared for three different coated particles using diagnosticmethods such as Raman spectroscopy, scanning electron microscopy, and confocal laser scanning microscopy. Based on the obtained results, it was concluded that the ion polishing method is better becausethe level of interference with the structures of the individual layers of the tested samples is much lowerthan with the mechanical method. The same technique is used for the fuel particles undergone ionimplantation simulating radiation damage that can occur in the reactor core.
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A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
Claire Hall,Louise Clarke,Atanu Pal,Pamela Buchwald,Tim Eglinton,Chris Wakeman,Frank Frizelle 대한대장항문학회 2019 Annals of Coloproctolgy Vol.35 No.6
Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.
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