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3차원 마이크로 파이버 플랫폼 구현을 통한 심장세포 수축력 변이 모델링
구상모(Sangmo Koo),Zhen Ma,Nathaniel Huebsch,Mohammad A. Mandegar,Brian Siemons,Steven Boggess,Bruce R. Conklin,Costas P. Grigoropoulos,Kevin E. Healy 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12
The integration of 3D artificial fibrous platform by advanced laser-based direct writing (two-photon polymerization), and human induced pluripotent stem cells (hiPSCs) allows us to measure the physiolocal phenotypes and recapitulation of diverse cardiac diseases. And additional genome editing technologies also make it possible to mimic the realistic disease pathologies. Based on those techniques, it was possible to create the patient-customized 3D platform by fabricating the 3D microscale fibrous structure which has similar mechanical properties such as stiffness for cardiac disease research. 3D cardiac tissues are anchored between two flexible cantilevers, contraction (and relaxation) force was measured by measuring fiber deflection. It is served as force sensor, and showed the tissue mechanical resistance to contraction can regulated by external microenvironments.