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RISS 인기검색어
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- 저자 : Boonprasert, Rattana (검색결과 2 건)
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Koedrith, Preeyaporn,Boonprasert, Rattana,Kwon, Jee Young,Kim, Im-Soon,Seo, Young Rok THE KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPRP 2014 MOLECULAR AND CELLULAR TOXICOLOGY Vol.10 No.2
Concomitant with the increase in production and application of various nanomaterials, researches on their cytotoxic and genotoxic potential have become well established, as exposure to these nanoscaled materials may contribute to detrimental health effects. Positive indications of the damaging effects of nanoparticles on DNA are likely to be inconsistent in in vitro systems, and thus the implementation of in vivo investigations has been achieved. This review summarizes the current results, both in vitro and in vivo, of the genotoxic effects of potential metal or metal oxide nanoparticles, including the oxides of aluminium, iron, silica, titanium, and zinc, as well as silver, gold, cobalt, quantum dots, and so forth. They present indications of different types of DNA damage, ranging from chromosomal aberrations, through DNA strand breaks, oxidative DNA damage, to mutations. Their toxicological profiles are definitely associated with physicochemical characters, depending upon the characterization methods by which they are analyzed, in particular, microscopy techniques. Besides physicochemical properties, we also discuss significant parameters that may influence genotoxic response, including toxicity assays/endpoint tests, exposure duration and route of exposure, and experimental conditions. We describe advantages and disadvantages of particular characterization methods, as well as the appropriateness of methodologies for investigating physicochemical characters. Therefore, recommendations on particle characterization are further emphasized, to provide better understanding of genotoxic potential.
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Koedrith, Preeyaporn,Thasiphu, Thalisa,Weon, Jong-Il,Boonprasert, Rattana,Tuitemwong, Kooranee,Tuitemwong, Pravate Hindawi Publishing Corporation 2015 The Scientific World Journal Vol.2015 No.-
<P>Of global concern, environmental pollution adversely affects human health and socioeconomic development. The presence of environmental contaminants, especially bacterial, viral, and parasitic pathogens and their toxins as well as chemical substances, poses serious public health concerns. Nanoparticle-based biosensors are considered as potential tools for rapid, specific, and highly sensitive detection of the analyte of interest (both biotic and abiotic contaminants). In particular, there are several limitations of conventional detection methods for water-borne pathogens due to low concentrations and interference with various enzymatic inhibitors in the environmental samples. The increase of cells to detection levels requires long incubation time. This review describes current state of biosensor nanotechnology, the advantage over conventional detection methods, and the challenges due to testing of environmental samples. The major approach is to use nanoparticles as signal reporter to increase output rather than spending time to increase cell concentrations. Trends in future development of novel detection devices and their advantages over other environmental monitoring methodologies are also discussed.</P>
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