THE SECOND MULTIPLE-PLANET SYSTEM DISCOVERED BY MICROLENSING: OGLE-2012-BLG-0026Lb, c-A PAIR OF JOVIAN PLANETS BEYOND THE SNOW LINE

Han, C.,Udalski, A.,Choi, J.-Y.,Yee, J. C.,Gould, A.,Christie, G.,Tan, T.-G.,Szymań,ski, M. K.,Kubiak, M.,Soszyń,ski, I.,Pietrzyń,ski, G.,Poleski, R.,Ulaczyk, K.,Pietrukowicz, P.,Kozłow IOP Publishing 2013 ASTROPHYSICAL JOURNAL LETTERS - Vol.762 No.2

<P>We report the discovery of a planetary system from observation of the high-magnification microlensing event OGLE-2012-BLG-0026. The lensing light curve exhibits a complex central perturbation with multiple features. We find that the perturbation was produced by two planets located near the Einstein ring of the planet host star. We identify four possible solutions resulting from the well-known close/wide degeneracy. By measuring both the lens parallax and the Einstein radius, we estimate the physical parameters of the planetary system. According to the best-fit model, the two planet masses are similar to 0.11 M-J and 0.68 M-J and they are orbiting a G-type main-sequence star with a mass similar to 0.82 M-circle dot. The projected separations of the individual planets are beyond the snow line in all four solutions, being similar to 3.8 AU and 4.6 AU in the best-fit solution. The deprojected separations are both individually larger and possibly reversed in order. This is the second multi-planet system with both planets beyond the snow line discovered by microlensing. This is the only such system (other than the solar system) with measured planet masses without sin i degeneracy. The planetary system is located at a distance 4.1 kpc from the Earth toward the Galactic center. It is very likely that extra light from stars other than the lensed star comes from the lens itself. If this is correct, it will be possible to obtain detailed information about the planet host star from follow-up observation.</P>

Chemopreventive Potential of Annona Muricata L Leaves on Chemically-Induced Skin Papillomagenesis in Mice

Hamizah, Sulaiman,Roslida, A.H.,Fezah, O.,Tan, K.L.,Tor, Y.S.,Tan, C.I. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Annona muricata L (Annonaceae), commonly known as soursop has a long, rich history in herbal medicine with a lengthy recorded indigenous use. It had also been found to be a promising new anti-tumor agent in numerous in vitro studies. The present investigation concerns chemopreventive effects in a two-stage model of skin papillomagenesis. Chemopreventive effects of an ethanolic extract of A. muricata leaves (AMLE) was evaluated in 6-7 week old ICR mice given a single topical application of 7,12-dimethylbenza(${\alpha}$)anthracene (DMBA 100ug/100ul acetone) and promotion by repeated application of croton oil (1% in acetone/twice a week) for 10 weeks. Morphological tumor incidence, burden and volume were measured, with histological evaluation of skin tissue. Topical application of AMLE at 30, 100 and 300mg/kg significantly reduced DMBA/croton oil induced mice skin papillomagenesis in (i) peri-initiation protocol (AMLE from 7 days prior to 7 days after DMBA), (ii) promotion protocol (AMLE 30 minutes after croton oil), or (iii) both peri-initiation and promotion protocol (AMLE 7 days prior to 7 day after DMBA and AMLE 30 minutes after croton oil throughout the experimental period), in a dose dependent manner (p<0.05) as compared to carcinogen-treated control. Furthermore, the average latent period was significantly increased in theAMLE-treated group. Interestingly, At 100 and 300 mg/kg, AMLE completely inhibited the tumor development in all stages. Histopathological study revealed that tumor growth from the AMLE-treated groups showed only slight hyperplasia and absence of keratin pearls and rete ridges. The results, thus suggest that the A.muricata leaves extract was able to suppress tumor initiation as well as tumor promotion even at lower dosage.

Properties of hydroxyapatite synthesize by wet chemical method

S. Ramesh,S. Adzila,C.K.L. Jeffrey,C.Y. Tan,J. Purbolaksono,A.M. Noor,M.A. Hassan,I. Sopyan,W.D. Teng 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.4

The sintering behavior of a commercial HA and synthesized HA was investigated over the temperature range of 700 o C to 1400 o C in terms of phase stability, bulk density, Young’s modulus and Vickers hardness. In the present research, a wet chemical precipitation reaction was successfully employed to synthesize a submicron, highly crystalline, high purity and single phase stoichiometric HA powder that is highly sinteractive particularly at low temperature regimes below 1100 o C. It has been revealed that the sinterability of the synthesized HA was significantly greater than that of the commercial HA. The temperature for the onset of sintering and the temperature required to achieve densities above 98% of theoretical value were approximately 150 o C lower for the synthesized HA than the equivalent commercial HA. Nevertheless, decomposition of HA phase upon sintering was not observed in the present work for both powders.

Hydraulic Force and Impeller Evaluation of a Centrifugal Heart Pump

Timms, D.L,Tan, A.C.C,Pearcy, M-J,Mcneil, K,Galbraith, A The Korean Society of Marine Engineering 2004 한국마린엔지니어링학회지 Vol.28 No.2

A rig was constructed to test the performance characteristics and compare the hydraulic forces exerted on a centrifugal type artificial heart impeller. A conventional shaft. seal and bearing system. while driven by a small electric motor. supported the impeller which was separated from the pump casing by a six degree of freedom force transducer (JR3 Ine). Radial (x. y) and axial (z) hydraulic forces were recorded and compared. At physiological operating conditions. the results indicate that the double entry/exit centrifugal pump encounters a smaller radial force and significantly reduced axial thrust. These experimental results are valuable in the design of a magnetic bearing system to suspend the impeller of a centrifugal artificial heart pump. This experimental technique may also be applied to evaluate the required capacity and predict the lifetime of contact bearings in marine pumps.

Topology of spin meron pairs in coupled Ni/Fe/Co/Cu(001) disks

Tan, A.,Li, J.,Scholl, A.,Arenholz, E.,Young, A. T.,Li, Q.,Hwang, C.,Qiu, Z. Q. American Physical Society 2016 Physical review. B Vol.94 No.1

<P>The meron is a special topological object that carries only one-half of the topological charge unit. In condensed matter physics, a spin meron corresponds to one-half of a spin skyrmion. As compared to the many fascinating topological properties of skyrmion materials, little is known of the properties of spin merons especially about their formation. It was confirmed only recently that hedgehog merons could exist in pairs with opposite helicities via a spin flux closure. However, it is unclear whether a single hedgehog meron could ever exist by pairing with another type of meron. Using element-resolved magnetic imaging measurements on epitaxial trilayer disks, we show that a spin meron with a full range of helicity, including the hedgehog meron, can be stabilized by pairing with another vortex meron with a fine tuning of the magnetic coupling between the two merons. Furthermore, the meron divergence is fully controlled by the polarity of the vortex meron, independent of the vortex helicity.</P>

Experimental Flow Visualisation of an Artificial Heart Pump

Tan, A.C.C.,Timms, D.L.,Pearcy, M.J.,McNeil, K.,Galbraith, A. The Korean Society of Marine Engineering 2004 한국마린엔지니어링학회지 Vol.28 No.2

Flow visualization techniques were employed to qualitatively visualize the flow patterns through a 400% scaled up centrifugal blood pump. The apparatus comprised of a scaled up centrifugal pump. high speed video camera. Argon Ion Laser Light Sheet and custom coded particle tracking software. Reynolds similarity laws are applied in order to reduce the rotational speed of the pump. The outlet (cutwater) region was identified as a site of high turbulence and thus a likely source of haemolysis. The region underneath the impeller was identified as a region of lower flow.

Mutations in SLC26A1 Cause Nephrolithiasis

Gee, H.Y.,Jun, I.,Braun, D.A.,Lawson, J.A.,Halbritter, J.,Shril, S.,Nelson, C.P.,Tan, W.,Stein, D.,Wassner, A.J.,Ferguson, M.A.,Gucev, Z.,Sayer, J.A.,Milosevic, D.,Baum, M.,Tasic, V.,Lee, M.G.,Hildebr University of Chicago Press [etc.] 2016 American journal of human genetics Vol.98 No.6

<P>Nephrolithiasis, a condition in which urinary supersaturation leads to stone formation in the urinary system, affects about 5%-10% of individuals worldwide at some point in their lifetime and results in significant medical costs and morbidity. To date, mutations in more than 30 genes have been described as being associated with nephrolithiasis, and these mutations explain about 15% of kidney stone cases, suggesting that additional nephrolithiasis-associated genes remain to be discovered. To identify additional genes whose mutations are linked to nephrolithiasis, we performed targeted next-generation sequencing of 18 hypothesized candidate genes in 348 unrelated individuals with kidney stones. We detected biallelic mutations in SLC26A1 (solute carrier family 26 member 1) in two unrelated individuals with calcium oxalate kidney stones. We show by immunofluorescence, immunoblotting, and glycosylation analysis that the variant protein mimicking p.Thr185Met has defects in protein folding or trafficking. In addition, by measuring anion exchange activity of SLC26A1, we demonstrate that all the identified mutations in SLC26A1 result in decreased transporter activity. Our data identify SLC26A1 mutations as causing a recessive Mendelian form of nephrolithiasis.</P>

Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line

Yusufi, F.N.K.,Lakshmanan, M.,Ho, Y.S.,Loo, B.L.W.,Ariyaratne, P.,Yang, Y.,Ng, S.K.,Tan, T.R.M.,Yeo, H.C.,Lim, H.L.,Ng, S.W.,Hiu, A.P.,Chow, C.P.,Wan, C.,Chen, S.,Teo, G.,Song, G.,Chin, J.X.,Ruan, X. Cell Press 2017 Cell systems Vol.4 No.5

Effective development of host cells for therapeutic protein production is hampered by the poor characterization of cellular transfection. Here, we employed a multi-omics-based systems biotechnology approach to elucidate the genotypic and phenotypic differences between a wild-type and recombinant antibody-producing Chinese hamster ovary (CHO) cell line. At the genomic level, we observed extensive rearrangements in specific targeted loci linked to transgene integration sites. Transcriptional re-wiring of DNA damage repair and cellular metabolism in the antibody producer, via changes in gene copy numbers, was also detected. Subsequent integration of transcriptomic data with a genome-scale metabolic model showed a substantial increase in energy metabolism in the antibody producer. Metabolomics, lipidomics, and glycomics analyses revealed an elevation in long-chain lipid species, potentially associated with protein transport and secretion requirements, and a surprising stability of N-glycosylation profiles between both cell lines. Overall, the proposed knowledge-based systems biotechnology framework can further accelerate mammalian cell-line engineering in a targeted manner.

Effect of manganese oxide on the densification and properties of ceria-doped scandia stabilized zirconia

C.K. Ng,S. Ramesh,C.Y. Tan,C.Y. Ching,N. Lwin,A. Muchtar 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.5

In the present work, the effect of manganese oxide (MnO2) additions (0, 0.5, 1 and 5 wt%) on the properties of ceria-dopedscandia stabilized zirconia (10Sc1CeSZ) was investigated over the temperature range of 1400 oC to 1550 oC. The results showedthat the addition up to 1 wt% had negligible effect on the mechanical properties of the ceramic. The samples containing upto 1 wt% MnO2 attained above 97.5% relative density, Vickers hardness of 13-14 GPa and fracture toughness of about3 MPam1/2. In addition, it was revealed that the 0.5 wt% MnO2 addition was beneficial in suppressing the cubic zirconia graingrowth i.e. the highest average grain size was measured at 4.9 µm when sintered at 1550 oC as compared to 9.9 µm measuredfor the undoped zirconia when sintered at the same temperature. On the other hand, the addition of 5 wt% MnO2 was foundto be detrimental to the densification and properties of the zirconia, particularly when sintered at higher temperatures. Thiswas attributed to the accelerated grain growth of the doped samples, i.e. the grain size increased by 2 fold, to 18.6 µm whensintered at 1550 oC.

Characteristics of Piezoceramics Sensors for Vibration Detection

Tan, A.C.C.,Dunbabin, M. The Korean Society of Marine Engineering 2004 한국마린엔지니어링학회지 Vol.28 No.2

Early detection of an internal malfunction of machinery plays a very important part in all condition monitoring programs. Sensors to detect amplitude. velocity and acceleration are widely used in vibration detection and control. Piezoceramic materials are largely used in sensors and actuators for vibration monitoring and control due to their relatively large output from an induced strain and their arguable self powering characteristics. In this paper a cheap and yet reliable sensors/actuators were developed to detect vibration. The results show that low cost PZT can be designed for optimum detection of bearing vibration. This paper presents the experimental results of a number of piezoceramics characteristics in terms of resonant frequencies and variation of PZT constants with temperature.