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최근 5년간 광주, 전남 지역에서 발생한 Stevens-Johnson 증후군과 중독성 표피 괴사융해증의 임상적 고찰
김은정 ( Eun Jung Kim ),이지범 ( Jee Bum Lee ),권용현 ( Yong Hyun Kwon ),윤숙정 ( Suk Jung Yun ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.5
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions which are most frequently caused by drugs. The incidence of SJS and TEN is known to be relatively low, however the outcomes may be fatal. Objectives: To investigate the clinical feature and outcome of 32 patients diagnosed with SJS and TEN. Methods: Thirty two patients (17 males, 15 females, mean age 50.8 years) with SJS and TEN, diagnosed at the Department of Dermatology, Chonnam National University Hospital from January 2001 to December 2005, were retrospectively evaluated. Results: Thirty two patients were clinically classified with SJS (n=15, 46.9%), overlap SJS/TEN (n=3, 9.4%) and TEN (n=14, 43.7%). Non-steroidal anti-inflammatory drugs (NSAIDs) were most commonly suspected as the causative drug in this series. All patients had involvement of the mucosa, except two. More than two sites were affected in 68.8 percent of cases. Nineteen patients (59.4%) showed abnormal liver function and three patients (9.4%) showed abnormal renal function. Five patients (15.6%) showed leukocytopenia and twenty four patients showed increased lactate dehydrogenase activity. Complications, mainly in the TEN group, included pneumonia, toxic hepatitis, wound infection, septicemia and multiorgan failure. Two patients died from septicemia and multiorgan failure. Conclusion: The mortality from SJS and TEN has been quoted as being about 5% and 30%, respectively. However, the mortality in our study was relatively low (SJS 0%, TEN 14.3%). Early intensive treatment is important for reducing the mortality rate in SJS/TEN. (Korean J Dermatol 2006;44(5):574~578)
630 nm Light Emitting Diode 조사가 인체섬유모세포의Caveolin-1과 전구콜라겐 I/III의 발현에 미친 영향
최다인 ( Da In Choi ),최지영 ( Jee Young Choi ),김상엽 ( Sang Yub Kim ),윤숙정 ( Suk Jung Yun ),이지범 ( Jee Bum Lee ),이승철 ( Seung Chul Lee ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.3
Background: Recent studies indicate that light-emitting diodes (LED) may represent a novel and effective anti-aginglight source for the skin. Among many candidate molecules known to control collagens, caveolin-1 (Cav-1) is knownto play an inhibitory role in cutaneous collagen metabolism. Objective: This study aimed to evaluate the effects of LED irradiation on the expression levels of Cav-1 andprocollagens (proCOLs) in human dermal fibroblasts (HDFs). Methods: Cultured HDFs were irradiated with 630 nm LED at different doses, and the mRNA and proteinexpression levels of Cav-1 and proCOLs I/III were analyzed. Results: In LED-irradiated HDFs, mRNA and protein levels of Cav-1 were found to be down-regulated, whereasthose of proCOLs I/III were up-regulated in a dose-dependent manner. A negative correlation between Cav-1 andproCOLs was verified in Cav-1 siRNA transfected HDFs. LED was moreover found to result in up-regulation oftransforming growth factor (TGF)-β1 and its receptors (TβRI, TβRII), SMAD1, and SMAD2 mRNA levels,indicating that LED may activate the TGF-1/TβR/SMAD pathway in HDFs. Conclusion: The anti-aging effects of 630 nm LED on human skin are likely mediated by up-regulation of proCOLsI/III and inhibition of Cav-1 expression levels in HDFs.