http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Multi-functional porous hydrogels for regenerative medicine
Soon Mo CHOI(최순모),Deepti Singh(팁티 싱),Yong Woo CHO(조용우),Tae Hwan OH(오태환),Sun Mi ZO(조선미),Sung Soo HAN(한성수) 제어로봇시스템학회 2012 제어로봇시스템학회 합동학술대회 논문집 Vol.2012 No.7
The aim of this work is to develop a novel biocompatible drug delivery carrier and tissue engineering scaffold with ability of controlled drug release and also tissue regeneration. We have synthesized HPMADMAEM copolymer based hydrogels loaded with Doxorubicin (DOX) and tested in vitro. In-vitro drug release profile exhibited pH sensitive behavior of the hydrogel. The hydrolytic degradation of gel and in vitro studies of polymer-doxorubicin conjugate and doxorubicin release from hydrogel matrix indicated that hydrogels were stable under acidic conditions (in buffers at pH 4.6. In both drug forms, polymer-doxorubicin conjugate and free doxorubicin could be released from the hydrogel scaffold at a rate depending directly on either the rate of drug diffusion from the hydrogel, or rate of hydrogel degradation or at rate controlled by a combination of the both processes. In-vitro analysis showed homogenous cell attachment and proliferation on synthesized hydrogel matrix.