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( Jin Tae Hong ),( Pushpa Saranya Kollipara ),( Do Hee Won ),( Chul Ju Hwang ),( Yu Yeon Jung ),( Heui Seoung Yoon ),( Mi Hee Park ),( Min Jong Song ),( Ho Sueb Song ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.2
In the present study, we investigated anti-cancer effect of snake venom activated NK cells (NK-92MI) in lung cancer cell lines. Weused snake venom (4 mg/ml) treated NK-92MI cells to co-culture with lung cancer cells. There was a further decrease in cancer cellgrowth up to 65% and 70% in A549 and NCI-H460 cell lines respectively, whereas 30-40% was decreased in cancer cell growthby snake venom or NK-92MI alone treatment. We further found that the expression of various apoptotic proteins such as that Bax,and cleaved caspase-3 as well as the expression of various death receptor proteins like DR3, DR4 and Fas was also further increased. Moreover, consistent with cancer cell growth inhibition, the DNA binding activity of NF-kB was also further inhibited aftertreatment of snake venom activated NK-92MI cells. Thus, the present data showed that activated NK cells could further inhibitlung cancer cell growth.