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- 저자 : ( Hanife Serife Aktas ) (검색결과 2 건)
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( Serife Hanife Aktas ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Hutchinson Gilfort Progeria Syndrome (HGPS) is an aging disease which encounters in childhood and includes a higher risk for atherosclerosis, cerebrovascular event, stroke and coronary artery disease. Angiodysplasia in the gastrointestinal (GIS) tract can be seen as a cause of hemorrhage rarely. 15 years female Progeria patient which the diagnose was established before. The patient admitted our center with dyspeptic symtoms such as neusea, vomit, bloating and described the blackness in the stool. In the patient`s history, GIS tract hemorrhage was occured and treated in the another region hospital, two months ago. In the physical examination, decreased subcutaneous fat tissue, thin skin structure, micrognaty, thin top and bottom lip structure were inspected. Cardiovascular and respiratory system examination displayed normal fi ndings. Melena was not examinated in rectal examination. Laboratory fi ndings were normal between ranges except mild hypochromic anemia and hypothyroidism; hemoglobin:12 g/dL (12 - 18), hematocrit: 38 % (37 -48), ferritin: 139 ng/mL (4. 6 - 204), iron: 19 μg/dL (50 - 170), TIBC:269(141-519) thyroidstimulan hormone (TSH) : 6. 1 mIU/L (0. 4 - 3. 4), free T4: 1. 0 ng/dL (0. 9 - 1. 5), anti thyroglobulin: 113 IU/mL (0 - 57), anti thyroid peroxidase:267 IU/mL (0 - 64), sedimentation: 39 mm/hour. Intact and diffuse type angiodysplasia on the gastric mucosa was identifi ed by the gastroscopy. There were no any bleeding signs and medical treatment (proton pump inhibitor and sucralfate) was applied. Also, hypothyroidism was treated by the levo-thyroxin preparate. For the mild hypochromic and iron defi cient anemia, iron containing preparate added to the treatment after discharge. In the literature, there was not coincided HGPS case with hemorrhagic angiodisplasia, commonly. This case report was represented to emphasize HGPS associated angiodisplasia as a rare cause of anemia and GIS tract hemorrhage.
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( Gulcin Gungor Olcum ),( Guven Koc ),( Fidan Canan Celik Yagan ),( Ece Yigit Taskin ),( Senem Ertilav ),( Hanife Serife Aktas ),( Sati Sena Yildiz ),( Demet Ataman Tasan ),( Fatih Akdogan ),( Sema Ba 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: RA is a chronic systemic disease manifest with multiple joint infi ammation. Vasculitis, heart, lung disease, extra-articular symptoms can also be present. TNF-a,IL-6 and mediators such as cytokines, have been shown to have an important role in this infi ammatory process. Anti-TNF drugs considered to be effective in preventing; RA,disability and joint destruction. CRP is one of the best indicators of infi ammation though, ESR is an indirect indicator of infi ammation and ESR levels affected by age, sex, status and anemia. ESR and CRP levels in patients with RA, disease activity and has been shown to correlate with radiographic fi ndings In this study, we aim to to show the correlation between ESR, CRP levels with disease activity in patients receiving anti-TNF alpha therapy. Methods: In this Retrospective study between January 2006 to March 2010 patients diagnosed with RA were evaluated in two groups. In the study group patients receiving at least one year of TNF-alpha were included where as in the control group patients only receiving DMARD were include. Only female patients were involved in both groups. There were 46 women in the study and 47 women in the control group. Disease severity and DAS 28 score was used to determine the disease activity. For statistical analysis Number Cruncher Statistical System 2007 & PASS 2008 Statistical Software (Utah,USA) was used. Results: In patients receiving anti-TNF alpha therapy DAS 28 scores showed statisticallysignifi cant correlation with the ESR. A statistically signifi cance between DAS 28 and CRP were not found. In control group with only DMARD treatment, the DAS 28.
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