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방기황기탕이 Monosodium Iodoacetate로 유발된 흰쥐의 골관절염에 미치는 영향
김태훈 ( Dae Hun Kim ),강성인 ( Sung In Kang ),송민영 ( Min Yeong Song ),최진본 ( Jin Bong Choi ),배길준 ( Kil Joon Bae ),한정식 ( Jeong Seok Han ),양미성 ( Mi Sung Yang ),신용진 ( Yong Jeen Sin ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.2
ObjectivesWe have studied to know effects of Bangkeehwangkee-tang on the mono-sodium iodoacetate (MIA) induced osteoarthritis in rats. Methods Osteoarthritis was induced by injection of monosodium iodoacetate into knee joint cavity of rats. Rats are devided into 4 groups; Sham, control, Bangkeehwangkee-tang, Shinbaro. Sham group was injected by normal saline into knee joint cavity only. Control group was taken no treatment and Experimental groups were taken extracts of Bangkee-hwangkee-tang and Shinbaro by orally once a day for 4 weeks. The content of TNF-α, IL- 1β and IL-6 in synovial fluids were analysed. COX-2 in chondrocytes and blood PGE2 concentration were analysed. Histopathological examination was performed by Safranin-O fast green staining and Mankins score checking. Results The content of TNF-α, IL-1β in experimental groups were decreased com-pared with control group. COX-2 in chondrocytes and blood PGE2 concentration in ex-perimental groups were decreased compared with control group. Histopathologically, os-teoarthritic scores of experimental groups were decreased compared with control group. But the content of IL-6 in synovial fluids was not significantly compared with control group. Conclusions According to these results, it can be suggested that Bangkeehwangkee- tang has anti-arthritic effects on the MIA induced osteoarthritis in rats. (J Korean Med Rehab 2014;24(2):15-29)