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Inhibition of Mutagenesis and Transformation by Root Extracts of Panax ginseng in vitro
Rhee, Y.H.,Ahn, J.H.,Choe, J.,Kang, K.W.,Joe, C. 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-
The root extract of Panax ginseng was investigated for its inhibitory effects on DNA synthesis, mutagenicity, and cellular transformation using V79 and NIH 3T3 cells. DNA synthesis measured by the [^3H]-thymidine incorporation into V79 Chinese hamster lung cells was significantly decreased by the addition of ginseng extract (0-1 ㎍/㎖) to the medium. However, ginseng extract was found to increase the rate of DNA excision repair synthesis in V79 cells in response to treatment with UV radiation or methyl methanesulfonate. The extract also showed decreased mutation frequency when mutagenicity was examined using V79 cells at the hypoxanthing-guanine phosphoribosyl transferase locus as resistance to 6-thioguaning after exposure to methyl methanesulfonate. We also found that the components of ginseng extract continue to exert an inhibitory effect on the transformation of NIH 3T3 cells initiated by 3-methylchloanthrene, methyl methanesulfonate, and 1-methyl-3-nitro-1-nitrosoguanidine.