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마이크로파 주사에 의해 촉진되는 Pd-MCM-41 촉매를 이용한 무용매 스즈키 반응
채금희 ( Keum Hee Chae ),장소라 ( So Ra Jang ),장원길 ( Won Ghil Chang ),안병준 ( Byoung Joon Ahn ) 전북대학교 과학교육연구소 2010 科學敎育論叢 Vol.35 No.-
The carbon-carbon bond formation reaction, such as Suzuki reaction, is a useful tool for the synthesis of biaryl and diaryl-substituted acetylenes. The reaction products are important building blocks for the synthesis of biologically active molecules and synthetic drugs. The development of active catalysts and the efficient reaction conditions for Suzuki reaction have been investigated in the view of environmentally benign green chemistry. Pd-modified MCM-41 was prepared by impregnation using an aquous solution of [Pd(NH3)4]Cl2 and characterized by using XRD, SEM, TEM, EPMA and BET Sorption Analyzer. The microwave-assisted Suzuki reactions are performed under solvent-free condition. Particularly Pd-MCM-41 was found to be best catalysts for these cross-coupling reactions due to the uniform Pd dispersion, unique channel structure and hydrophilic surface property. K2CO3 base was found to be the most efficient base in the microwave-assisted Suzuki cross coupling reaction of phenylboronic acid with iodobenzene. Microwave-assisted coupling reaction under the solvent-free condition was accelerated in a shorter time than it was in the thermal reaction and showed good to excellent yield. The major goal of green chemistry is to maximize the use of starting materials, to increase process selectivity, and to replace hazardous and stoichiometric reagents with eco-friendly catalysts in order to facilitate easy separation of the product. The use of Pd-MCM-41 as catalyst in Suzuki reactions was found to be very suitable to the aim of green chemistry.