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정영호,황영수,주층노,백용기 한국지질학회 1992 韓國脂質學會誌 Vol.2 No.1
The effects of colestipol and ginseng saponin on serum lipid levels in normal, cholesterol-fed and atherogenic diet-fed mice were examined by serum lipid analysis. In atherogenic diet-fed mice, the levels of total serum cholesterol and triglyceride were increased by 200% and 190% respectively. The rise in total serum cholesterol and triglyceride in atherogenic diet fed groups were not directly influenced by the cholesterol contents of atherogenic diets. Ginseng saponin treatment on the same groups has resulted in reduction of total serum cholesterol and triglyceride by 42% and 38% respectively. Colestipol treatment on this diet-fed group appears to lower atherogenesis index suggesting that cotestipol play an important role of depression of atherosclerosis. However, treatment of colestipol and ginseng saponin seem to have negative effect on the changes in total concentration of HDL lipids in atherogenic diet-fed mice.