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결절성 경화증 환자에서 경막하 거대세포 성상세포종의 감마나이프와 수술치료 1례
정모경(Mo Kyung Jung),이상미(Sang Mi Lee),유리타(Rita Yu),김흥동(Heung Dong Kim),이준수(Joon Soo Lee),김동석(Dong Suk Kim),강훈철(Hoon-Chul Kang) 대한소아신경학회 2013 대한소아신경학회지 Vol.21 No.3
저자들은 결절성 경화증에서 흔하게 동반될 수 있는 SEGA가 있는 환자에서 GK-SRS를 시행하여 초기 경과가 좋았으나, 재발을 하여 결국 수술적 절제를 시행하게 된 증례를 경험하여 이를 보고하였다. Subependymal giant cell astrocytoma (SEGA) is the most common brain tumor that develops in 5-20% of patients with tuberous sclerosis complex. Although these lesions are slowly growing tumor, they can cause morbidity and mortality due to acute hydrocephalus because of their prevalent location near the foramen of Monro. Surgery has been the standard care for SEGAs demonstrating serial growth and symptomatic hydrocephalus. However, not all SEGAs are treatable by complete surgical resection. Gamma Knife stereotactic radiosurgery can be considered as a second option, but it has shown highly variable responses in patients with limited data. In recent years, drugs with novel mechanism, sirolimus and other mammalian target of rapamycin (mTOR) inhibitors have been found to reduce the size of SEGAs. We report a case of treatment of SEGA with gamma knife surgery which continued for two years without progression, even though surgical resection was done, finally.