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아포지단백(Apolipoprotein) ε4 유전자형과 치매환자의 인지기능, 일상생활기능 및 행동증상
김영돈(Young-Don Kim),이창화(Chang-Hwa Lee),엄기춘(Ki-Choon Eum),김동희(Dong-Hee Kim),윤경식(Kyeong-Sik Yoon) 대한노인정신의학회 2002 노인정신의학 Vol.6 No.1
Objectives:We investigated the relationship between apolipoprotein ε4 and clinical features of dementia. Methods:Samples were obtained from 33 dementia patients in Korea, Buyeo Geriatric Hospital and apolipoprotein E polymorphisms were analysed using polymerase chain reaction and restriction fragment length polymorphism. The multidimensional evaluating methods (MMSE-K, B-ADL, BEHAVE-AD, GDS, GMHR) for dementia were performed to analyze relationship with Apolipoprotein E genotypes. Results:The distributions of the apolipoprotein E genotypes of the dementia patients were presented by ε3/ε3 (58%), ε3/ε4 (22%), ε2/ε3 (15%), and ε4/ε4 (0%). There is no significant relationship between apolipoprotein ε4 and the findings of multidimensional evaluating measures. Conclusion:We could not find the association between apolipoprotein ε4 and the scores of the multidimensional evaluating measures of dementia patients. The results suggested that apolipoprotein ε4 might not play a main role in cognitive function, daily living ability and behavioral symptoms of dementia.