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LDH(Layered Double Hydroxides)와 최적의 전달체를 이용한 레티놀 안정화에 관한 연구
박영아(Young-Ah Park),우영롱(Young-Rong Woo),지홍근(Hong-Geun Ji),유효경(Hyo-Gyeong Yu),나건(Gun Na),이종현(Jong-Hyeon Lee) 한국화장품미용학회 2015 한국화장품미용학회지 Vol.5 No.3
A recent development in cosmetics has extensively required the high functionality of cosmetic raw materials to increase their stability for light, heat and oxygen in air which can seriously reduce their biological activities. So, it is essential to develop new technologies for the stabilization of the raw materials. With this trend, we have focused on the development of new stabilization methods for major vitamin based cosmetics such as Retinol. Retinol is one of important vitamins with a wide variety of biological functions such as embryonic growth and development, vertebrate vision, immune reactions, and epidermal differentiation. It is also prime candidate for cancer chemoprevention. However, all vitamins show decreased biological activities by isomerization and photochemical and thermal oxidation. These degradation reactions inevitably reduce their available vitamin activities in stored and processed foods. It is also well-known that the environmental conditions such as high humidity, low pH and high temperature significantly decrease the stability of retinol and its relatives. To overcome these problems, we have investigated the encapsulation of the retinol by using adaptable vesicles and layered double hydroxides.
폴리라이신아스팔틱산 (Poly(aspartic acid))과 그 유도체를 담지한 나노 입자의 주름 개선 효과에 관한 연구
우영롱(Young-Rong Woo),지홍근(Hong-Geun Ji),유효경(Hyo-Gyeong Yu),장혜인(Hye-in Jang) 한국화장품미용학회 2016 한국화장품미용학회지 Vol.6 No.1
Polymers such as polyacrylate, polysaccharide, polyamino acid and polypeptide are widely used in cosmetics and pharmaceutical. They were used for viscosity agent, emulsifying agent and carriers for delivery of drugs. However we studied polymer as activity agent, especially synthesized poly(aspartic acid). Poly(aspartic acid) is one of biocompatible synthetic polymer and is water-soluble polyamide containing carboxylic pendants that can be prepared form polysuccinimide, the polycondensate of aspartic acid monomer, by hydrolysis. In this study, we prepared the poly(aspartic acid) derivatives conjugated with L-lysine or L-lyine and other materials. The chemical sturucture of these polymers were confirmed by FT-IR and 1H-NMR spectroscopy. And we could estimate that these novel poly(aspartic acid) derivatives had the stimulation effect of type Ⅰ collagen biosynthesis and MMP-1(collagenase) inhibition activity.