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유전자를 중간 매개로 고려한 동시발생 기반의 약물-질병 관계 추론
신상원(Sangwon Shin),신예은(Yeeun Sin),장기업(Giup Jang),윤영미(Youngmi Yoon) 한국정보기술학회 2018 한국정보기술학회논문지 Vol.16 No.11
Drug repositioning is to discover new uses of drugs. Text mining derives knowledge from unstructured text. We propose a method to predict new drug-disease relationships by taking into account the rate of frequency of genes simultaneously measured in disease-gene and gene-drug. Co-occurrence of drug-gene and gene-disease in the biological literature is counted and calculate the rate of the gene for each drug and disease. Weights of drug-disease relationships are calculated using the average of the rates of genes that are measured and used to measure the accuracy for each disease. In measuring drug-disease relationships, a more accurate identification of relationships was shown by measuring the frequency on a sentence and considering multiple relationships than existing method.