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rhBMP-2의 작용기전과 구강악안면 영역의 골재생을 위한 rhBMP-2의 활용
황순정(Soon Jung Hwang),박민우(Min-Woo Park),박재봉(Jae bong Park),박현수(Hyun Soo Park),백승준(Seung-Jun Paek),설희경(Hee-Kyung Sul),이경진(Kyung jin Lee),홍동환(Dong-Hwan Hong) 대한치과의사협회 2015 대한치과의사협회지 Vol.53 No.1
To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP 2 is regarded as the most potent osteoinductive growth factor and it can trigger the differentiation of mesenchymal stem cells to osteogenic cells for accelerated new bone formation And several commercial products of rhBMP 2 are available in Korea. It is applied to maxillary sinus augmentation, guided bone regeneration and preservation of extraction socket. In this review, the development, action mechanism and clinical applications of rhBMP 2 will be described.