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캠핀기반 공압출법을 이용한 기공구조가 제어된 생체세라믹 스캐 폴드 개발
문영욱(Young-Wook Moon),신관하(Kwan-Ha Shin),고영학(Young-Hag Koh) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
We herein propose a new technique for producing highly aligned porous bioceramic scaffolds with various structures using camphene-based freeze casting, which includes bioceramic scaffolds with highly aligned pores, tubular scaffolds with aligned porous walls and sandwich-structured scaffolds having tailored porous structures. This new technique makes full use of camphene as a deformable pore-forming agent, which would be elongated extensively by co-extrusion, allowing the creation of aligned pores in bioceramic scaffolds produced after sintering at high temperatures. The porous structure and mechanical properties of the produced scaffolds were evaluated. The process ability and utility of the present technique have been discussed.
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최원영,김현이,문영욱,신관하,고영학 한국생체재료학회 2015 생체재료학회지 Vol.19 No.3
Background: Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, these materials with an open porous structure can stimulate bone ingrowth into their 3-dimensionally interconnected pores. However, the creation of pores in bulk materials would inevitably cause a severe reduction in mechanical properties. Thus, it is a challenge to explore new ways of improving the mechanical properties of porous CaP scaffolds without scarifying their high porosity. Results: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion. This aligned porous structure allowed for the achievement of high compressive strength when tested parallel to the direction of aligned pores. In addition, the overall porosity and mechanical properties of the aligned porous CaP ceramic scaffolds could be tailored simply by adjusting the initial CaP content in the CaP/camphene slurry. The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold. Conclusions: Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.
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