http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
3 - ( 치환 ( X ) - phenyl ) - 1 - ( 2 - furyl ) propenone 유도체의 항균활성
성낙도(Nack Do Sung),강희덕(Hee Deog Kang),맹주앙(Joo Yang Maeng),신동린(Dong Rin Shin) 한국응용생명화학회 1994 Applied Biological Chemistry (Appl Biol Chem) Vol.37 No.4
New 3-phenyl-1-(2-furyl)propenones, 1 and 3-phenyl-1-(2-furyl)-3-thiophenyl-propanone, 2 derivatives were synthesized, and their fungicidal activities in vitro against Botrytis cineria (BC), Valsa ceratosperma (VC), Scelerotium cepivorum (SC) and Phytophthora capsici (PC) were investigated using a generalized structure-activity relationship (SAR). The activity of 1 was superior to those of 2, and nonsubstituent, 1a and chloro group substituent, 1d of E (Syn) conformer were the most effective (EC_(50)=10∼12 ppm) compound to BC. Antifungal activities were able to predict to depend essentially on the β carbon and their positive charge from the results that the good correlation (r²= 0.90) was observed between hydrolysis rate constant (logk) of 1 and the electronic parameter (σ) of X-substituent on the β-phenyl ring.