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심정훈,마미라,함승욱 중앙대학교 기초과학연구소 2000 基礎科學硏究所 論文集 Vol.14 No.-
The early reports have indicated that menadione (vitamin K3) exerts antitumor activity by inhibiting Cdkl activity and overexpressing th c-myc gene to induce an apoptotic cell death. It was alsofound that a thioether analog of vitamin K inhibited the activity of protein tyrosine phosphatases and induced protein tyrosine phosphorylarion in a human hepatoma cell line (Hep3B). Because of the potential arylating activity of thioether analog of vitamin K, it might inhibit Cdc25 phosphatases, which comtain a cystein in the catalytic site. To test this hypothesis we examine the inhibitory activity of this compound against several phosphatases and found that this compound was a potent inhibitor of Cdc25 phosphatases.