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Lactiplantibacillus plantarum WiKim0125 균주의 발효 최적화 및 스케일 업 공정 개발
김영열(Yeong Yeol Kim),김슬비(Seulbi Kim),김정환(Jung Hwan Kim),김호명(Ho Myeong Kim) 한국유산균프로바이오틱스학회 2023 Current Topic in Lactic Acid Bacteria and Probioti Vol.9 No.1
In probiotics production, lactic acid bacteria (LAB) are cultured on a large scale to achieve efficient processing through fermentation optimization and scale-up. In this Current study, the LAB strain Lactiplantibacillus plantarum WiKim0125 was isolated from kimchi and optimized the production. The optimization strategy for cultivating L. plantarum WiKim0125 consisted of investigating media components, selecting physiochemical conditions to enhance productivity, and scaling up for pilot-scale production. Each process condition was evaluated based on substrate consumption, lactic acid production, and viable cell yield. As a result, the final viable cell and lactic acid yield of L. plantarum WiKim0125 increased by 38.6% and 19.4%, respectively. This study provides an overview of fermentation optimization and scale-up processes for the industrial application of L. plantarum WiKim0125.