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- 저자 : 고호준(Ho Joon Ko) (검색결과 1 건)
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고호준(Ho Joon Ko),장해인(Hae In Jang),조형민(Hyoung Min Cho),김은영(Eun Young Kim),김경심(Kyoung Sim Kim),김용욱(Yong Wook Kim),김령(Young Kim) 조선대학교 의학연구원 2021 The Medical Journal of Chosun University Vol.46 No.1
Background: The incidence of intestinal metaplasia(IM) of stomach mucosa in children was reported ranging from approximately 1 to 3 percent. But, clinical implications, treatment, long-term prognosis, and surveillance protocols of this finding are not well established in this population. Study Objectives: This study aimed to evaluate the relationship between Helicobacter pylori (HP) infection and IM, and the treatment and long-term consequences of IM. Methods: During 6.5 years from March 2013 through August 2019, endoscopy with CLO test and multiple non-targeted biopsies were performed on 423 children and adolescents, 1 to 20 years of age, with alarm features associated with ulcer disease and gastritis. The clinical and laboratory records, macroscopic and microscopic findings of endoscopy were reviewed retrospectively. Results: Thirty-two cases (7.6%) of IM were identified. Two cases (6.3%) with HP infection were detected in 32 cases of IM, and 38 cases (9.7%) in 391 cases of non-IM. The Odds ratio was 0.619 (0.142-2.693). Proton pump inhibitor (PPI) was prescribed for six months in all cases of IM, and endoscopic follow-up was performed after a year in 11 cases. The disappearance of IM was detected in 6 cases (18.8%). Conclusions: The association of HP infection and IM was very low. After six months of PPI medication, the disappearance of IM was detected in a few cases. A close and prolonged clinical and endoscopic follow-up is needed for children and adolescents with IM.
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