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거대세포바이러스 감염을 동반한 선천성 흉선이형성증 1 예
이상일(Sang Il Lee),남승연(Seung Yeon Nam),강미애(Mee Ae Kang),안강모(Kang Mo Ahn),고영재(Young Jae Koh),서연림 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2000 소아알레르기 및 호흡기학회지 Vol.10 No.2
N/A Twenty-four months old female child was expired with disseminated Cytomegalovirus infections. The child had a history of intrauterine and postnatal growth retardation and recurrent episodes of upper respiratory tract infection. At the age of 17 months, she had idiopathic thrombocytopenic purpura which was unresponded to intravenous immunoglobulin and steroid. Depending upon the bone marrow biopsy finding at the age of 21 months, myelodysplastic syndrome was suspected and she was treated with chemotherapy(Ara-C). Two months later, pancytopenia was developed with severe pneumonia. Cytomegalovirus was isolated from trachea, blood and urine, and she died. Postmorterm examination revealed congenital thymic dysplasia, which was characterized by a mass of mescenchymal and endothelial cells with occasional lymphocytes and the absence of Hassall`s corpuscles. Lymph nodes were composed of supporting tissue without follicular differentiation. Cytomegaloviral inclusions were found in the endothelial or epithelial cells of visceral organs including lung, heart, liver, pancreas, gastrointestinal tract, thymus, spleen, lymph nodes, retina, brain, kidney and adrenal glands.