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AQUATIDE Plays a Role as Innovative Skin-Care Vaccine Through The Autophagy Induction
( Chaejin Lim ),( Myungho Kor ),( Seokjeong Yoon ),( Heungjae Kim ),( Kyungho Park ),( Keedon Park ) 한국피부장벽학회 2016 한국피부장벽학회지 Vol.18 No.2
Natural moisturizing factor (NMF) in the stratum corneum has a high moisture retaining efficacy, and plays a major role in the skin barrier function. Pyrrolidone carboxylic acid (PCA) is one of the major NMFs found in human skin. Aquatide, a PCA-mimetic peptide, improves the skin barrier function by stimulating filaggrin expression as well as reducing Trans-Epidermal Water Loss (TEWL) correlated with increased water retention and moisturization. Autophagy is the natural destructive mechanism that allows the orderly degradation and recycling of cellular damaged components. So, Increased autophagy delays ageing process and extends longevity. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. AQUATIDE alleviates ROS- and heavy metal-mediated senescence and cytotoxicity of cells by SIRT1-dependent autophagy. Furthermore, AQUATIDE reduces pollen-mediated PGE2 release and keeps the skin healthy during an allergic reaction against pollen treatment. In conclusion, AQUATIDE is considered as the first needle-free “skin-care vaccine” for various troubled skins including inflamed and irritated skin as well as aged skin.
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