Polymorphisms of TERT and CLPTM1L and the Risk of Hepatocellular Carcinoma in Chinese Males

Su, Ling-Yan,Li, Xue-Lian,Shen, Li,Zhang, Yue,Zhao, Meng-Meng,Yin, Zhi-Hua,Su, Hong-Ying,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes located on chromosome 5p15.33 are known to influence the susceptibility to various cancers. Here, we examined the association of TERT and CLPTM1L single nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC). Materials and Methods: Genotyping of TERT SNP rs2736098 and CLPTM1L SNP rs401681 was performed using TaqMan allelic discrimination assays in a case-control study of 201 HCC cases and 210 controls in a Chinese male population. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression analyses. Results: Both the rs2736098 T allele of TERT and the rs401681 T allele of CLPTM1L were associated with a significantly increased risk of HCC (adjusted odds ratio [OR]=1.605, 95% confidence interval [CI]=1.164-2.213; adjusted OR=1.399, 95%CI=1.002-1.955, respectively). Individuals carrying both TERT and CLPTM1L risk genotypes had an even higher risk of HCC (adjusted OR=4.420, 95%CI= 2.319-8.425). The TERT rs2736098 T allele was also significantly associated with the level of the HCC clinical indicator alpha-fetoprotein (P=0.026). Conclusions: Our results show that genetic variants of TERT and CLPTM1L may contribute to HCC susceptibility in Chinese males.

Study on an Optimal Control Method for Energy Injection Resonant AC/AC High Frequency Converters

Su, Yu-Gang,Dai, Xin,Wang, Zhi-Hui,Tang, Chun-Sen,Sun, Yue The Korean Institute of Power Electronics 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.2

In energy injection resonant AC-AC converters, due to the low frequency effect of the AC input envelope and the low energy injection losses requirement, the constant and steady control of the high frequency AC output envelope is still a problem that has not been solved very well. With the aid of system modeling, this paper analyzes the mechanism of the envelope pit on the resonant AC current. The computing methods for the critical damping point, the falling time and the bottom value of the envelope pit are presented as well. Furthermore, this paper concludes the stability precondition of the system AC output. Accordingly, an optimal control method for the AC output envelope is put forward based on the envelope prediction model. This control method can predict system responses dynamically under different series of control decisions. In addition, this control method can select best series of control decisions to make the AC output envelope stable and constant. Simulation and experimental results for a contactless power transfer system verify the control method.

Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy

Su, Meng,Yin, Zhi-Hua,Wu, Wei,Li, Xue-Lian,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Background: The ataxia telangiectasia mutated (ATM) protein and p53 play key roles in sensing and repairing radiation-induced DNA double strand breaks (DSBs). Accumulating epidemiological evidence indicates that functional genetic variants in ATM and TP53 genes may have an impact on the risk of radiotherapy-induced side effects. Here we performed a meta-analysis to investigate the potential interaction between ATM Asp1853Asn and TP53 polymorphisms and risk of radiotherapy-induced adverse effects quantitatively. Materials and Methods: Relevant articles were retrieved from PubMed, ISI Web of Science and the China National Knowledge Infrastructure (CNKI) databases. Eligible studies were selected according to specific inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to estimate the association between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and risk of radiotherapy adverse effects. All analyses were performed using the Stata software. Results: A total of twenty articles were included in the present analysis. In the overall analysis, no significant associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and the risk of radiotherapy adverse effects were found. We conducted subgroup analysis stratified by type of cancer, region and time of appearance of side effects subsequently. No significant association between ATM Asp1853Asn and risk of radiotherapy adverse effects was found in any subgroup analysis. For TP53 Arg72Pro, variant C allele was associated with decreased radiotherapy adverse effects risk among Asian cancer patients in the stratified analysis by region (OR=0.71, 95%CI: 0.54-0.93, p=0.012). No significant results were found in the subgroup analysis of tumor type and time of appearance of side effects. Conclusions: The TP53 Arg72Pro C allele might be a protective factor of radiotherapy-induced adverse effects among cancer patients from Asia. Further studies that take into consideration treatment-related factors and patient lifestyle including environmental exposures are warranted.

LARGE SCHR¨ODER PATHS BY TYPES AND SYMMETRIC FUNCTIONS

Su Hyung An,Sen-Peng Eu,Sangwook Kim 대한수학회 2014 대한수학회보 Vol.51 No.4

In this paper we provide three results involving large Schr¨oder paths. First, we enumerate the number of large Schr¨oder paths by type. Second, we prove that these numbers are the coefficients of a certain symmetric function defined on the staircase skew shape when expanded in elementary symmetric functions. Finally we define a symmetric function on a Fuss path associated with its low valleys and prove that when expanded in elementary symmetric functions the indices are running over the types of all Schr¨oder paths. These results extend their counterparts of Kreweras and Armstrong-Eu on Dyck paths respectively.

A Shared Channel Design for the Power and Signal Transfers of Electric-field Coupled Power Transfer Systems

Su, Yu-Gang,Zhou, Wei,Hu, Aiguo Patrick,Tang, Chun-Sen,Hua, Rong The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2

Electric-field coupled power transfer (ECPT) systems have been proposed as an alternative wireless power transfer (WPT) technology in recent years. With the use of capacitive plates as a coupling structure, ECPT systems have many advantages such as design flexibility, reduced volume of the coupling structure and metal penetration ability. In addition, wireless communications are effective solutions to improve the safety and controllability of ECPT systems. This paper proposes a power and signal shared channel for electric-field coupled power transfer systems. The shared channel includes two similar electrical circuits with a band pass filter and a signal detection resistor in each. This is designed based on the traditional current-fed push-pull topology. An analysis of the mutual interference between the power and signal transmission, the channel power and signal attenuations, and the dynamic characteristic of the signal channel are conducted to determine the values for the electrical components of the proposed shared channel. Experimental results show that the designed channel can transfer over 100W of output power and data with a data rate from 300bps to 120 kbps.

New metabolites from the sponge-derived fungus <i>Aspergillus sydowii</i> J05B-7F-4

Liu, Sen,Wang, Haibo,Su, Mingzhi,Hwang, Gwi Ja,Hong, Jongki,Jung, Jee H. Taylor & Francis Health Sciences 2017 NATURAL PRODUCT RESEARCH Vol.31 No.14

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Intercalated Treatment Following Rebiopsy Is Associated with a Shorter Progression-Free Survival of Osimertinib Treatment

Jeng-Sen Tseng,Tsung-Ying Yang,Kun-Chieh Chen,Kuo-Hsuan Hsu,Yen-Hsiang Huang,Kang-Yi Su,Sung-Liang Yu,Gee-Chen Chang 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose Epidermal growth factor receptor (EGFR) T790M mutation serves as an important predictor of osimertinib efficacy. However, little is known about how it works among patients with various timings of T790M emergence and treatment. Materials and Methods Advanced EGFR-mutant lung adenocarcinoma patients with positive T790M mutation in tumor were retrospectively enrolled and observed to determine the outcomes of osimertinib treatment. We evaluated the association between patients’ characteristics and the efficacy of osimertinib treatment, particularly with respect to the timing of T790M emergence and osimertinib prescription. Results A total of 91 patients were enrolled, including 14 (15.4%) with primary and 77 (84.6%) with acquired T790M mutation. The objective response rate and disease control rate were 60.9% and 85.1%, respectively. The median progression-free survival (PFS) and overall survival were 11.5 months (95% confidence interval [CI], 9.0 to 14.0) and 30.4 months (95% CI, 11.3 to 49.5), respectively. There was no significant difference in response rate and PFS between primary and acquired T790M populations. In the acquired T790M subgroup, patients who received osimertinib after T790M had been confirmed by rebiopsy had a longer PFS than those with intercalated treatments between rebiopsy and osimertinib prescription (14.0 months [95% CI, 9.0 to 18.9] vs. 7.2 months [95% CI, 3.7 to 10.8]; adjusted hazard ratio, 0.48 [95% CI, 0.24 to 0.98; p=0.043]). Rebiopsy timing did not influence the outcome. Conclusion Osimertinib prescription with intercalated treatment following rebiopsy but not the timing of T790M emergence influenced the treatment outcome. We suggest that it is better to start osimertinib treatment once T790M mutation has been confirmed by biopsy.

An Anti-Inflammatory PPAR-γ Agonist from the Jellyfish-Derived Fungus <i>Penicillium chrysogenum</i> J08NF-4

Liu, Sen,Su, Mingzhi,Song, Shao-Jiang,Hong, Jongki,Chung, Hae Young,Jung, Jee H. American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.2

<P>An investigation of the jellyfish-derived fungus <I>Penicillium chrysogenum</I> J08NF-4 led to the isolation of two new meroterpene derivatives, chrysogenester (<B>1</B>) and 5-farnesyl-2-methyl-1-<I>O</I>-methylhydroquinone (<B>2</B>), and four known farnesyl meroterpenes. Docking analysis of <B>1</B> showed that it binds to PPAR-γ in the same manner as the natural PPAR-γ agonist amorfrutin B (<B>7</B>). Compound <B>1</B> activated PPAR-γ in murine Ac2F liver cells and increased nuclear PPAR-γ protein levels in murine RAW 264.7 macrophages. Because one of the main biological functions of PPAR-γ agonists is to suppress inflammatory response, an <I>in vitro</I> study was performed to explore the anti-inflammatory potency of <B>1</B> and the mechanism involved. In RAW 264.7 macrophages, <B>1</B> inhibited phosphorylation of the NF-κB p65 subunit and suppressed the expression of the pro-inflammatory mediators iNOS, NO, COX-2, TNF-α, IL-1β, and IL-6. We propose <B>1</B> suppresses inflammatory responses by activating PPAR-γ and subsequently downregulating the NF-κB signaling pathway, thus reducing the expressions of pro-inflammatory mediators.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2018/jnprdf.2018.81.issue-2/acs.jnatprod.7b00846/production/images/medium/np-2017-008469_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np7b00846'>ACS Electronic Supporting Info</A></P>

차아염소산나트륨 가스의 저장 종자 소독 효과

백수봉,박종선 建國大學校 附設 農業資源開發硏究所 1999 農資源開發論集 Vol.21 No.-

ABSTRACT The effect of disinfection by sodium hypochloride gas exposure on postharvest seed on 4 food crops like rice, barley, soybean, corn, and 4 vegetable crops like sesame, red pepper, radish, chinese cabbage was investigated at 6h, 12h and 24h treatment. Although the disinfection value was shown 95.5%~100.0% in food crops seeds there was no recognized significant difference between treatments. The germination percentage and embrynic axis elongation was no effect but root elongation on corn was some effect at 6h treatment. In vegetable crops seeds, the disinfection value was shown 100.0%, but there was no recognized significant difference on the germination percentage and root elongation between treatment.

LARGE SCHRÖDER PATHS BY TYPES AND SYMMETRIC FUNCTIONS

An, Su Hyung,Eu, Sen-Peng,Kim, Sangwook Korean Mathematical Society 2014 대한수학회보 Vol.51 No.4

In this paper we provide three results involving large Schr$\ddot{o}$der paths. First, we enumerate the number of large Schr$\ddot{o}$der paths by type. Second, we prove that these numbers are the coefficients of a certain symmetric function defined on the staircase skew shape when expanded in elementary symmetric functions. Finally we define a symmetric function on a Fuss path associated with its low valleys and prove that when expanded in elementary symmetric functions the indices are running over the types of all Schr$\ddot{o}$der paths. These results extend their counterparts of Kreweras and Armstrong-Eu on Dyck paths respectively.