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- 저자 : ( Sedat Abusoglu ) (검색결과 1 건)
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( Hamit Yasar Ellidag ),( Nurullah Bulbuller ),( Esin Eren ),( Sedat Abusoglu ),( Evren Akgol ),( Mustafa Cetiner ),( Necat Yilma ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.6
Background/Aims: An impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases, including cancer. The aim of this study was to evaluate the levels of the novel marker ischemia-modified al-bumin (IMA) and albumin-adjusted IMA (Adj-IMA) in patients with colorectal cancer (CRC) and look for the associations of these with the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI). Methods: Forty patients with CRC (19 females and 21 males; mean age, 56.5±2.1 years) and 39 age- and sex-matched healthy peo-ple (22 females and 17 males; mean age, 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, and TOS were analyzed, and the OSI was calculated. Results: Serum IMA, TOS, and OSI levels were significantly higher in patients with CRC than in controls (p<0.0001), whereas TAS levels were significantly lower in CRC patients (p=0.03). There was no significant difference in serum Adj-IMA levels between groups (p=0.32). Conclusions: In this study, the oxidative/antioxidant status was impaired in favor of oxida-tive stress in CRC patients. This observation was not con-firmed by IMA measurement. Further studies are needed to establish the relationship between IMA and oxidative stress parameters in CRC and other cancers. (Gut Liver 2013;7:675-680)
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