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Animal care and use programs: Global Harmonization Through Alternatives
( Kathryn Bayne ) 한국동물실험대체법학회 2007 한국동물실험대체법학회 학술대회집 Vol.2007 No.1
At an accelerating pace, the application of the 3Rs to the design and conduct of animal experiments has spread worldwide in the laboratory animal science community. What was once regarded with some skepticism is now widely viewed as a credible, and indeed scientific, approach to animal-based research. As the principles of reduction, refinement and replacement are more broadly implemented, a natural outcome is that certain procedures are used in preference to others because they enhance both animal welfare and the quality of the data collected, meet the criteria of the 3Rs, have been scientifically validated, and may be more economic. Animal care and use program elements are being harmonized as new research is published on alternative routine experimental procedures and animal husbandry practices. For example, alternative housing environments have been developed for certain species of laboratory animals for which urine and / or feces must be collected through the elimination of metabolic cages, refinements have been made to the cage environment through the provision of environmental enrichment, and animal housing environments have been generally improved through the design of cage equipment that enhances animal well-being. Meetings of experts from around the world have been held to discuss and come to consensus on common practices in the research laboratory, such as euthanasia of rodents by carbon dioxide and alternative methods of husbandry have been published, such as new methods of rodent identification. To facilitate the ongoing search for alternatives which improve laboratory animal welfare and animal research data, international collaboration and communication is essential, and opportunities for this communication and collaboration must continue to be given priority.